Nano-Coupling of Cephalosporin Antibiotics with Fe<SUB>3</SUB>O<SUB>4</SUB>Nanoparticles: Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by <i>Klebsiella spp</i>.  

作　　者：Ulviyya Alimammad Hasanova Mahammadali Ahmad Ramazanov Abel Mammadali Maharramov Qoncha Malik Eyvazova Zohrab Adalet Agamaliyev Yana Vacheslav Parfyonova Sarvinaz Faiq Hajiyeva Flora Vidadi Hajiyeva Solmaz Bayram Veliyeva 

机构地区：[1]Baku State University, Nano Research Laboratory, Baku, Azerbaijan

出　　处：《Journal of Biomaterials and Nanobiotechnology》2015年第3期225-235,共11页生物材料与纳米技术（英文）

摘　　要：In the present study we had an aim to develop the methods of functionalizing the surface of magnetite nanoparticles with cefotaxime and ceftriaxone antibiotics. The quantitative analysis of the nanostructured cephalosporins was determined by Atom Absorbance Spectroscopy (AAS) and based on the Lambert-Beer law. The engineered nanostructures were tested on gram-negative microorganisms Klebsiella spp., of Enterobacteriaceae, and gram-positive bacteria Staphylococcus aureus, each having multi-drug resistance properties.In the present study we had an aim to develop the methods of functionalizing the surface of magnetite nanoparticles with cefotaxime and ceftriaxone antibiotics. The quantitative analysis of the nanostructured cephalosporins was determined by Atom Absorbance Spectroscopy (AAS) and based on the Lambert-Beer law. The engineered nanostructures were tested on gram-negative microorganisms Klebsiella spp., of Enterobacteriaceae, and gram-positive bacteria Staphylococcus aureus, each having multi-drug resistance properties.

关 键 词：Magnetite NANOPARTICLES CEPHALOSPORIN CEFOTAXIME Ceftriaxone KLEBSIELLA Staphylococcus aureus 

分 类 号：R5[医药卫生—内科学]