A validated, related substance, GC method for 1,4-cyclohexanedione mono-ethylene Ketal  

作　　者：B. Karthikeyan V. Srinivasan 

机构地区：[1]Department of Chemistry Annamalai university, Annamalainagar, India

出　　处：《Journal of Biophysical Chemistry》2010年第1期72-75,共4页生物物理化学（英文）

摘　　要：ABSTRACT A simple, economic, and time-efficient related substance, GC method has been developed for the analysis of 1,4-Cyclohexanedione mono- ethylene ketal(will be specified as ketal) in the presence of a potential impurity 1,4-cyclohexa- nedione bis (ethylene ketal) [will be specified as diketal]. Successful chromatographic separa- tion of the ketal from the impurity was achieved on a DBWAX ETR, 30 m x 0.32 mm x 1.0μ FT column with nitrogen as carrier gas and FID detector. The method was validated for linearity, accuracy, precision, and specificity and can be used for quality control during manufacture of ketal. A validated GC method is reported for the ketal for the first time.ABSTRACT A simple, economic, and time-efficient related substance, GC method has been developed for the analysis of 1,4-Cyclohexanedione mono- ethylene ketal(will be specified as ketal) in the presence of a potential impurity 1,4-cyclohexa- nedione bis (ethylene ketal) [will be specified as diketal]. Successful chromatographic separa- tion of the ketal from the impurity was achieved on a DBWAX ETR, 30 m x 0.32 mm x 1.0μ FT column with nitrogen as carrier gas and FID detector. The method was validated for linearity, accuracy, precision, and specificity and can be used for quality control during manufacture of ketal. A validated GC method is reported for the ketal for the first time.

关 键 词：Column Gas CHROMATOGRAPHY 1 4-Cyclohexanedione Mono-Ethylene KETAL 4-Cyclohexanedione BIS (Ethylene Ketal) Validation 

分 类 号：O6[理学—化学]