Synthesis, Characterization and Anticancer Activity Studies of New Schiff Base Pt (II) Complex  

作　　者：Sama A. Al-Aghbari Omar M. Al-Shuja’a Rowaida Al-Badani Abd Al-Wali M. Japir 

机构地区：[1]Chemistry Department, Faculty of Pharmacy, University of Science & Technology, Sana’a, Yemen [2]Chemistry Department, Faculty of Applied Science, Thamar University, Thamar, Yemen [3]CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China [4]Department of Chemistry, Faculty of Education, Thamar University, Dhamar, Yemen

出　　处：《Journal of Materials Science and Chemical Engineering》2019年第8期1-8,共8页材料科学与化学工程（英文）

摘　　要：A New Schiff base ligand and its Pt (II) complex were synthesized. The ligand was prepared by condensation of 2-(4-isobutylphenyl)propanehydrazide with 2,3,4-trihydroxy benzaldehyde this novel ligand and its functional group was carefully designed and selected from well-known biological drugs. The structure of the ligand and its Pt-complex have been confirmed by spectroscopic data, i.e. elemental (CHN) analysis, FT-IR, electronic spectra, NMR spectra. The ligand and its Pt-complex were investigated for their in vitro anticancer potential using HeLa and PC3 cells. The Pt-complex showed a higher cytotoxic activity than the ligand towards Hela cells and PC3 cells.A New Schiff base ligand and its Pt (II) complex were synthesized. The ligand was prepared by condensation of 2-(4-isobutylphenyl)propanehydrazide with 2,3,4-trihydroxy benzaldehyde this novel ligand and its functional group was carefully designed and selected from well-known biological drugs. The structure of the ligand and its Pt-complex have been confirmed by spectroscopic data, i.e. elemental (CHN) analysis, FT-IR, electronic spectra, NMR spectra. The ligand and its Pt-complex were investigated for their in vitro anticancer potential using HeLa and PC3 cells. The Pt-complex showed a higher cytotoxic activity than the ligand towards Hela cells and PC3 cells.

关 键 词：SCHIFF BASE COMPLEXES PLATINUM ANTICANCER Activity 

分 类 号：O6[理学—化学]