Hydrothermal Synthesis and Characterization of Copper Glycinate (Bio-MOF-29) and Its <i>in Vitro</i>Drugs Adsorption Studies  

作　　者：Tabinda Sattar Muhammad Athar 

机构地区：[1]Instituite of chemical sciences, B.Z.U Multan, Pakistan

出　　处：《Open Journal of Inorganic Chemistry》2017年第2期17-27,共11页无机化学期刊（英文）

摘　　要：A new porous compound, Copper glycinate (Bio-MOF-29), [Cu(C2H4NO2)2 (H2O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P212121 space group. In vitro adsorption studies of four different drugs, terazosine hydrochloride, telmisartan, glimpiride and rosuvastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfuly adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.A new porous compound, Copper glycinate (Bio-MOF-29), [Cu(C2H4NO2)2 (H2O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P212121 space group. In vitro adsorption studies of four different drugs, terazosine hydrochloride, telmisartan, glimpiride and rosuvastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfuly adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.

关 键 词：Bio-Metal Organic Framework Glycine Single Crystal XRD Analysis High Performance Liquid Chromatography Terazosine HCl TELMISARTAN Glimpiride Rosuvastatin Bio-MOF-29 

分 类 号：O6[理学—化学]