Synthesis and Antibacterial Activities of New 2-(Benzylthio)pyrimidines and 2-(Benzimidazolylmethylthio)pyrimidines Derivatives  

作　　者：Achi Patrick-Armand Coulibali Siomenan Zon Doumade Timotou Adéyolé Bolou Eric Touré Daouda Sissouma Drissa Adjou Ané Achi Patrick-Armand;Coulibali Siomenan;Zon Doumade;Timotou Adéyolé;Bolou Eric;Touré Daouda;Sissouma Drissa;Adjou Ané(Laboratoire de Constitution et Réaction de la Matière, UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët Boigny de Cocody, Abidjan, Côte d’Ivoire;Département de Mathématiques-Physique-Chimie, UFR des Sciences Biologiques, Université Peleforo Gon Coulibaly, Korhogo, Côte d’Ivoire;Centre National de Floristique, Université Félix Houphouët-Boigny de Cocody, Abidjan, Côte d’Ivoire;Département de Biochimie-Génétique, UFR des Sciences Biologiques, Université Peleforo Gon Coulibaly, Korhogo, Côte d’Ivoire)

机构地区：[1]Laboratoire de Constitution et Réaction de la Matière, UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët Boigny de Cocody, Abidjan, Côte d’Ivoire [2]Département de Mathématiques-Physique-Chimie, UFR des Sciences Biologiques, Université Peleforo Gon Coulibaly, Korhogo, Côte d’Ivoire [3]Centre National de Floristique, Université Félix Houphouët-Boigny de Cocody, Abidjan, Côte d’Ivoire [4]Département de Biochimie-Génétique, UFR des Sciences Biologiques, Université Peleforo Gon Coulibaly, Korhogo, Côte d’Ivoire

出　　处：《Open Journal of Medicinal Chemistry》2021年第3期27-39,共13页药物化学期刊（英文）

摘　　要：A series of 2-<span style="font-family:Verdana;">(</span><span style="font-family:Verdana;">benzylthio</span><span style="font-family:Verdana;">)</span><span style="font-family:;" "=""><span style="font-family:Verdana;">pyrimidines (</span><b><span style="font-family:Verdana;">6a-l</span></b><span style="font-family:Verdana;">) and</span></span><span style="font-family:Verdana;"> 2-(benzimidazolylmethylthio</span><span style="font-family:Verdana;">)-</span><span style="font-family:;" "=""><span style="font-family:Verdana;">pyrimidines derivatives (</span><b><span style="font-family:Verdana;">6m</span></b><span style="font-family:Verdana;"> and </span><b><span style="font-family:Verdana;">6n</span></b><span style="font-family:Verdana;">) analogues of ethyl 2-(benzylthio)-6-methyl-</span></span><span style="font-family:Verdana;">4-phenyl-1,4-dihydropyrimidine-5-carboxylates and ethyl 2-(((1H-benzimi</span><span style="font-family:;" "=""><span style="font-family:Verdana;">da</span><span style="font-family:Verdana;">zol-</span></span><span style="font-family:Verdana;">2-yl)methyl)thio)-6-methyl-4-phenyl-1,4-dihydropyri</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">midine-5-carboxy</span><span style="font-family:Verdana;">l</span><span style="font-family:Verdana;">ates</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">were prepared and evaluated for antibacterial activity. These com</span><span style="font-family:;" "=""><span style="font-family:Verdana;">pounds were </span><span><span style="font-family:Verdana;">obtained by condensation of 2-thiopyrimidines (</span><b><span style="font-family:Verdana;">4</span></b><span style="font-family:Verdana;">) with benzyl halides or</span></span><span style="font-family:Verdana;"> 2-</span></span><span style="font-family:;" "=""><span style="font-family:Verdana;">(chloromethyl)-</span><i><span style="font-family:Verdana;">1H</span></i><span style="font-family:Verdana;">-benzimidazole (</span><b><span styleA series of 2-<span style="font-family:Verdana;">(</span><span style="font-family:Verdana;">benzylthio</span><span style="font-family:Verdana;">)</span><span style="font-family:;" "=""><span style="font-family:Verdana;">pyrimidines (</span><b><span style="font-family:Verdana;">6a-l</span></b><span style="font-family:Verdana;">) and</span></span><span style="font-family:Verdana;"> 2-(benzimidazolylmethylthio</span><span style="font-family:Verdana;">)-</span><span style="font-family:;" "=""><span style="font-family:Verdana;">pyrimidines derivatives (</span><b><span style="font-family:Verdana;">6m</span></b><span style="font-family:Verdana;"> and </span><b><span style="font-family:Verdana;">6n</span></b><span style="font-family:Verdana;">) analogues of ethyl 2-(benzylthio)-6-methyl-</span></span><span style="font-family:Verdana;">4-phenyl-1,4-dihydropyrimidine-5-carboxylates and ethyl 2-(((1H-benzimi</span><span style="font-family:;" "=""><span style="font-family:Verdana;">da</span><span style="font-family:Verdana;">zol-</span></span><span style="font-family:Verdana;">2-yl)methyl)thio)-6-methyl-4-phenyl-1,4-dihydropyri</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">midine-5-carboxy</span><span style="font-family:Verdana;">l</span><span style="font-family:Verdana;">ates</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">were prepared and evaluated for antibacterial activity. These com</span><span style="font-family:;" "=""><span style="font-family:Verdana;">pounds were </span><span><span style="font-family:Verdana;">obtained by condensation of 2-thiopyrimidines (</span><b><span style="font-family:Verdana;">4</span></b><span style="font-family:Verdana;">) with benzyl halides or</span></span><span style="font-family:Verdana;"> 2-</span></span><span style="font-family:;" "=""><span style="font-family:Verdana;">(chloromethyl)-</span><i><span style="font-family:Verdana;">1H</span></i><span style="font-family:Verdana;">-benzimidazole (</span><b><span style

关 键 词：2-Thiopyrimidine Benzylthiouracil BENZIMIDAZOLE Antibacterial Activity 

分 类 号：O62[理学—有机化学]