Anti-Melanogenesis Effect of Daniellic Acid Isolated from <i>Daniellia oliveri</i>(Rolfe) Hutch. &Dalziel (Leguminosae) Oleoresin of Burkina Faso  

作　　者：Aminata P. Nacoulma Moussa Compaoré Naamwin-so-Bawfu Romaric Meda Laurent Pottier Véronique Megalizzi Issa Some Martin Kiendrebeogo Aminata P. Nacoulma;Moussa Compaoré;Naamwin-so-Bawfu Romaric Meda;Laurent Pottier;Véronique Megalizzi;Issa Some;Martin Kiendrebeogo(Laboratoire de Toxicologie, Environnement et Santé, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso;Microbiology, Bioorganic and Macromolecular Chemistry and RD3—Pharmacognosy, Bioanalysis & Drug Discovery Units, Université libre de Bruxelles, Brussels, Belgium;Laboratoire de Biochimie et de Chimie Appliquées, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso)

机构地区：[1]Laboratoire de Toxicologie, Environnement et Santé, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso [2]Microbiology, Bioorganic and Macromolecular Chemistry and RD3—Pharmacognosy, Bioanalysis & Drug Discovery Units, Université libre de Bruxelles, Brussels, Belgium [3]Laboratoire de Biochimie et de Chimie Appliquées, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso

出　　处：《Open Journal of Medicinal Chemistry》2021年第4期41-57,共17页药物化学期刊（英文）

摘　　要：Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from </span>^{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">H-NMR, </span>^{<span style="font-family:Verdana;">13</span>}<span style="font-family:Verdana;">C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC</span>_{<span style="font-family:Verdana;">50</span>}<span style="font-family:Verdana;"> going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibit</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> tyrosinase activity with 1.20 mM as IC</span>_{<span style="font-family:Verdana;">50</span>}<span style="font-family:Verdana;">. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-faOver the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from </span>^{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">H-NMR, </span>^{<span style="font-family:Verdana;">13</span>}<span style="font-family:Verdana;">C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC</span>_{<span style="font-family:Verdana;">50</span>}<span style="font-family:Verdana;"> going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibit</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> tyrosinase activity with 1.20 mM as IC</span>_{<span style="font-family:Verdana;">50</span>}<span style="font-family:Verdana;">. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-fa

关 键 词：Daniellia oliveri Daniellic Acid Tyrosinase MELANOGENESIS Cytotoxicity 

分 类 号：O17[理学—数学]