云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(30570424)

国家自然科学基金(30570424): 作品数：11被引量：14H指数：3; 导出分析报告; 相关作者：李霞郭政朱晶张敏张帆更多>>; 相关机构：哈尔滨医科大学首都医科大学浙江大学电子科技大学更多>>; 相关期刊：《Science China(Life Sciences)》《中国生物医学工程学报》《Progress in Natural Science:Materials International》《科学通报》更多>>; 相关主题：GENEPROTEIN-PROTEINMICROARRAYSNPINTERACTION更多>>; 相关领域：生物学医药卫生农业科学更多>>

Mapping and characterization of two relevance networks from SNP and gene levels: 《Progress in Natural Science:Materials International》2009年第5期653-657,共5页Wei Jiang a,1, Lijie Zhang b,1, Bo Na a, Lihong Wanga, Jiankai Xu a, Xia Li a,b,c, Yadong Wangb, Shaoqi Rao da College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, China b Department of Mathematics and Computer Science, Harbin Institute of Technology, Harbin 150080, China c Department of Bioinformatics, Capital University of Medical Sciences, Beijing 100084, China d Department of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, 9600 Euclid Avenue, Cleveland, OH 44195, USA; supported by the National Natural Science Foundation of China (Grant Nos. 30370798,30571034 and 30570424);the National Hi-Tech Research and Development Program of China (Grant No.2007AA02Z329);the National Program on Key Basic Research Projects (Grant No. 2008CB517302); Variations of gene expression and DNA sequence are genetically associated. The goal of this study was to build genetic networks to map from SNPs to gene expressions and to characterize the two different kinds of netwo...; 关键词：SNP relevance network Gene relevance network Network mapping Network topology

基于Web的水稻芯片数据注释和分析平台被引量：1: 《中国科学（C辑）》2009年第3期323-332,共10页陈迪俊张帆吴超李霞陈铭; 国家自然科学基金(批准号:30500106,30570424,30571034,30600367和30771326);国家高技术研究发展计划(批准号:2007AA02Z329和2008AA10Z125);国家重点基础研究发展计划前期研究专项(批准号:2008CB517302);浙江省科技支撑和引导计划(批准号:2007C22025);黑龙江科技攻关计划(批准号:GB03C602-4)资助项目; 国际水稻基因组测序计划(IEGSP)顺利完成,水稻基因的研究也进入了后基因组研究阶段.水稻基因芯片数据注释分析是一项重要的功能基因组学研究内容,它为理解水稻基因的生物学意义提供了帮助.本研究开发了一个基于Web的水稻基因芯片数据注...; 关键词：水稻基因芯片注释和分析平台功能基因组

Identifying drug-target proteins based on network features被引量：3: 《Science China(Life Sciences)》2009年第4期398-404,共7页ZHU MingZhu1, GAO Lei1, LI Xia1,2 & LIU ZhiCheng1 1 School of Biomedical Engineering, Capital Medical University, Beijing 100069, China 2 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China; Supported by National Natural Science Foundation of China (Grant No. 30370798, 30571034 and 30570424);National High-Tech Research and Development Program of China (Grant No. 2007AA02Z329);National Basic Research Program of China (Grant No. 2008CB517302); Natural Science Foundation of Heilongjiang Province, China (Grant No. ZJG0501, 1055HG009, GB03C602-4 and BMFH060044); New Century Hundred-Thousand-Ten Thousand Talents Project of Beijing City, Scientific Research Common Program of Beijing Municipal Commission of Education (KM200610025011).; Proteins rarely function in isolation inside and outside cells, but operate as part of a highly intercon- nected cellular network called the interaction network. Therefore, the analysis of the properties of drug-targe...; 关键词：drug-target PROTEIN-PROTEIN INTERACTION TOPOLOGICAL FEATURES

结合蛋白质互作与功能类的可分性预测蛋白质功能: 《中国生物医学工程学报》2009年第2期270-274,共5页朱明珠高磊李彦辉马文才朱晶张敏郭政李霞; 国家自然科学基金资助项目(30571034,30370798,30570424,30600367);2006年北京市新世纪百千万人才工程;北京市教育委员会科技发展计划资助项目(KM200610025011); 当前蛋白质功能注释体系的欠完备性限制了生物学及医药研究的进一步发展和应用,有必要将基因本体功能知识体系(GO)的功能注释信息进一步深化,把蛋白质注释到GO中更具体的功能节点。为此,提出一种结合互作信息的新的预测策略,将酵母蛋白...; 关键词：蛋白质功能深化预测基因本体功能知识体系(GO) 预测空间

Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge framework: 《Science China(Life Sciences)》2009年第2期163-172,共10页ZHANG RuiJie1, LI Xia1,2, JIANG YongShuai1, LIU GuiYou1, LI ChuanXing1, ZHANG Fan1, XIAO Yun1 & GONG BinSheng1 1 Department of Bioinformatics, Harbin Medical University, Harbin 150086, China 2 Biomedical Engineering Institute of CUMS, Beijing 100054, China; Supported by the National Natural Science Foundation of China (Grant Nos. 30570424, 60601010 and 30600367);the National High-Tech Research and Devel-opment Program of China, (Grant No.2007AA02Z329);the Key Science and Tech-nology Program of Heilongjiang Province(Grant No.GB03C602-4);Natural Science Foundation of Heilongjiang Province (Grant No. F2008-02);Youth Science Founda-tion of Harbin Medical University (Grant No. 060045);Science Foundation of Heilongjiang Province Education Department (Grant Nos. 11531113 and 1152hq28).; High-throughout single nucleotide polymorphism detection technology and the existing knowledge provide strong support for mining the disease-related haplotypes and genes. In this study, first, we apply four kinds of h...; 关键词：HAPLOTYPE block ALCOHOLISM GENE functional ANNOTATION GENE location LINKAGE disequilibrium

A feature ensemble technology to identify molecular mechanisms for distinction between multiple subtypes of lymphoma被引量：2: 《Progress in Natural Science:Materials International》2008年第12期1491-1500,共10页Yueying Yang Haiyun Wang Xia Li Xue Xiao Su Fei Chuanxing Li Hongzhi Wang Shaoqi Rao Yadong Wang; supported in part by the National High Tech Development Project of China (Grant No.2007AA02Z329);the National Natural Science Foundation of China (Grant Nos.30571034,30570424 and 20060213024);the grant for Outstanding Overseas Scientist,Department of Education,Heilongjiang Province (Grant No.1055HG009);Natural Science Foundation of Heilongjiang Province (Grant Nos.ZJG0501,GB03C602-4 and F2004-02);Health Department of Heilongjiang Province Key Project (2005-39); Due to complexities and genetic heterogeneities of biological phenotypes, robust computational approaches are desirable to achieve high generalization performance with multiple classifiers, perturbations of the data s...; 关键词：Ensemble decision approach Molecular mechanisms LYMPHOMA MICROARRAY

Cell cycle-dependent gene networks relevant to cancer: 《Progress in Natural Science:Materials International》2008年第8期945-952,共8页Yun Xiao Xia Li Yueying Yang Yadong Wang Shaoqi Rao; the National High-Tech Development Project of China (Grant No.2007AA02Z329);National Natural Science Foundation of China (Grant Nos. 30170515, 30370798, 30571034,30570424 and 60601010);Outstanding Overseas Scientist Grant of the Heilongjiang Province (Grant No.1055HG009);National Science Foundation of Heilongjiang Province (Grant Nos. ZJG0501, GB03C602-4 and F2004-02);Health Department of Heilongjiang Province Key Project (2005-39).; The analysis of sophisticated interplays between cell cycle-dependent genes in a disease condition is one of the largely unexplored areas in modern tumor biology research. Many cell cycle-dependent genes are either on...; 关键词：Cell cycle MICROARRAY HeLa cell Gene network

结合已有知识体系的酒精中毒相关的SNP单体型及其相关基因挖掘被引量：1: 《中国科学（C辑）》2008年第10期938-948,共11页张瑞杰李霞姜永帅刘桂友李传星张帆肖云宫滨生; 国家自然科学基金(批准号:30570424,60601010和30600367);国家高技术研究发展计划(批准号:2007AA02Z329);黑龙江科技攻关(批准号:GB03C602-4);黑龙江自然科学基金(批准号:F2004-02);哈尔滨医科大学青年科学基金(批准号:060045);黑龙江省教育厅科学基金(批准号:11531113和1152hq28)资助项目; 高通量的单核苷酸多态(single nucleotide polym orphism,SNP)检测技术与已有的知识体系(如KEGG,GO数据库等)为与疾病相关的SNP单体型及相关基因挖掘提供了有力支撑.本研究对高通量SNP基因型数据,采用4种SNP单体型板块(block)识别方法(...; 关键词：单体型板块酒精中毒基因功能注释基因定位连锁不平衡

基于网络特征的药物靶蛋白识别被引量：1: 《中国科学（C辑）》2008年第12期1184-1190,共7页朱明珠高磊李霞刘志成; 国家高技术研究发展计划(批准号:2007AA02Z329);国家自然科学基金(批准号:30571034,30370798,30570424和30600367);北京市新世纪百千万人才工程、北京市教育委员会科技发展计划(批准号:KM200610025011)资助项目; 蛋白质很少孤立得发挥作用,往往通过网络中彼此互作来共同行使功能.因此分析药物靶蛋白在生物学网络中的性质将十分有助于从信息学角度理解药物的作用机制.但目前尚无研究对药物靶蛋白在人类蛋白质互作网络中的拓扑特性给与具体的分析...; 关键词：药物靶点蛋白质互作拓扑特征

Widely predicting specific protein functions based on protein-protein interaction data and gene expression profile被引量：3: 《Science China(Life Sciences)》2007年第1期125-134,共10页GAO Lei1, LI Xia1,2, GUO Zheng1,2, ZHU MingZhu1, LI YanHui1 & RAO ShaoQi1,3 1 Department of Bioinformatics, Harbin Medical University, Harbin 150086, China 2 School of Biology Science and Technology, Tongji University, Shanghai 200092, China 3 Departments of Molecular Cardiology and Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleve-land, Ohio 44195, USA; the National Natural Science Foundation of China (Grant Nos. 30170515, 30370388, 30370798, 30570424 and 30571034),;the National High Tech Development Project of China (Grant Nos. 2003AA2Z2051 and 2002AA2Z2052),;Heilongjiang Science & Technology Key Project (Grant No. GB03C602-4),;Harbin (City) Science & Technology Key Project (Grant No. 2003AA3CS113),;Natural Science Foundation of Heilongjiang (Grant No. F0177 ),;Outstanding Overseas Scientist Foundation of Education Department of Heilongjiang Province (Grant No. 1055HG009); GESTs (gene expression similarity and taxonomy similarity), a gene functional prediction approach previously proposed by us, is based on gene expression similarity and concept similarity of functional classes defined ...; 关键词：GENE expression profile PROTEIN-PROTEIN interaction GENE ONTOLOGY SIMILARITY GENE function prediction

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