supports from the Ministry of Science and Technology of China(Nos. 2012ZX09506001-010,2012AA020305 and 2011DFA30620);the National Natural Science Foundation of China(Nos.21272134 and 20902053);Shenzhen Sci & Tech Bureau(No. JCYJ20120831165730905)
Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers.Discovery of new multi-target scaffolds are important for developing such agents. A series ...