supported by the National Natural Science Foundation of China(Grant No.20925313 and 21090342);the National Basic Research Program of China(Grant No.2006CB910302);the Chinese Academy of Sciences Innovation Program(Grant No.KJCX2-YW-W25)
Protein could carry out its biological function only when it is folded into the right conformation,and the conformation might be changing during the activation process,therefore protein dynamical structure provides a ...