Supported by the National Natural Science Foundation of China (No 30271596), the Chinese Ministry of Science and Technology (No 2004CB518902 and 2005CB523403), and the Science & Technology Commission of Shanghai Municipality (No 01DJ19008 and 04DZ19215). Chuan LI designed research; Jie-yu DAI and Jun-ling YANG performed research;Chuan LI, Jie-yu DAI, and Junling YANG analyzed data; Chuan LI wrote the paper.
Aim: To investigate the limiting factors for oral bioavailability of flavonoids derived from the Chinese herbal remedy Xiaochaihu-tang. The investigational flavonoids included baicalin, wogonoside, oroxylin-A 7-O-β-...