国家自然科学基金(31171064)

作品数：6被引量：13H指数：3
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磷脂双分子层的修饰对电压门控钠通道的门控特性和药理学特性的影响(英文)被引量：2
《生理学报》2015年第3期271-282,共12页祝艳 吴彬 冯逸俊 陶杰 吉永华 
supported by the National Basic Research Development Program of China(No.2010CB529806);National Natural Science Foundation of China(No.31171064 and 30772554);Leading Academic Discipline Project of Shanghai Municipal Education Commission“Molecular Physiology”(No.J50108);Innovation Program of Shanghai Municipal Education Commission(No.15ZZ063);Research Project of Putuo Hospital,Shanghai University of Traditional Chinese Medicine,China(No.2014YJ002)
电压门控钠通道广泛分布于各类细胞和组织中,参与许多生理功能的调节。作为位于脂质双分子层的膜蛋白,周围的质膜成分对于其门控特性和药理学特性是否存在影响仍然未知。本研究采用全细胞膜片钳技术,以两种钠通道的特异性调制剂BmK I和B...
关键词：鞘磷脂酶D 钠通道 ND7-23细胞系 BMK I BMK AS 
脊髓5-HT3A受体对BmK I诱发的大鼠炎性痛的影响(英文)被引量：4
《生理学报》2015年第3期283-294,共12页傅晋 焦云露 李正威 吉永华 
supported by the National Natural Science Foundation of China(No.31171064)
通过皮下注射BmK I能够建立新型大鼠疼痛模型。五羟色胺（5-HT）受体参与调控动物疼痛相关行为。本文旨在研究5-HT3受体调控BmK I诱发疼的潜在机制。应用动物行为学、RT-PCR、蛋白印迹等技术手段进行相关研究,得到如下结果：足底注射Bm...
关键词：BMK I诱发痛 5-HT3A受体 小胶质细胞 痛觉超敏与敏化 
Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes
《Neuroscience Bulletin》2014年第4期697-710,共14页Heng Zhang Hui Ji Zhirui Liu Yonghua Ji Xinmin You Gang Ding Zhijun Cheng 
supported by grants from the National Natural Science Foundation of China (31171064);the Key Research Program of Science and Technology Commissions of Shanghai Municipality (11JC1404300,13DJ1400300);with financial support from Xinhua Hospital (Chongming),Shanghai Jiaotong University School of Medicine
Bupivacaine ranks as the most potent and efficient drug among class I local anesthetics, but its high potential for toxic reactions severely limits its clinical use. Although bupivacaine-induced toxicity is mainly cau...
关键词：BUPIVACAINE NAV1.5 voltage-dependentblockade inactivated state 
Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulator被引量：4
《Neuroscience Bulletin》2014年第1期21-32,共12页Feng Jiang Li-Ming Hua Yun-Lu Jiao Pin Ye Jin Fu Zhi-Jun Cheng Gang Ding Yong-Hua Ji 
supported by grants from the National Basic Research Development Program of China(2010CB529806);the National Natural Science Foundation of China(31171064);the Shanghai Science and Technology Commission;China(11JC1404300;10411956700 and 124119b0600)
The mammalian target of rapamycin （mTOR） pathway is essential for maintenance of the sensitivity of certain adult sensory neurons. Here, we investigated whether the mTOR cascade is involved in scorpion envenomation-...
关键词：BmK I mTOR p70 ribosomal S6 protein kinase 4E-binding protein 1 PAIN dorsal rootganglion 
Martentoxin:一种大电导钙激活钾离子通道的独有配体(英文)被引量：1
《生理学报》2012年第4期355-364,共10页陶杰 施健 刘志睿 吉永华 
supported by the National Basic Research Development Program of China (No. 2010CB529806);National Natural Sciences Foundation of China (No. 30772554 and 31171064);Key Research Program of Science and Technology Commissions of Shanghai Municipality,China (No. 11JC1404300);Leading Academic Discipline Project of Shanghai Municipal Education Commission "Molecular Physiology" (No. J50108);the Innovation Foundation for Graduate Student,Shanghai University,China
大电导钙激活钾离子(BK)通道广泛分布于可兴奋细胞与非兴奋细胞中,行使着一系列重要的生理功能。以源于蝎粗毒的高亲和性毒素作为研究工具,使BK通道的药理学和结构性质正逐步被揭示。Martentoxin是一种分离提取自东亚短钳蝎(Buthus mart...
关键词：BK通道 martentoxin 钙离子敏感性 Β亚基 毒素-通道相互作用 
Pharmacological kinetics of BmK AS, a sodium channel site 4-specific modulator on Na_v1.3被引量：6
《Neuroscience Bulletin》2012年第3期209-221,共13页Zhi-Rui Liu Jie Tao Bang-Qian Dong Gang Ding Zhi-Jun Cheng Hui-Qiong He Yong-Hua Ji 
supported by grants from the National Basic Research Development Program of China (2010CB529806);the National Natural Science Foundation of China (31171064);the Key Research Program of Science and Technology Commissions of Shanghai Municipality (11JC1404300);the Leading Academic Discipline Project of Shanghai Municipal Education Commission (J50108)
Objective In this study, the pharmacological kinetics of Buthus martensi Karsch （BmK） AS, a specific modulator of voltage-gated sodium channel site 4, was investigated on Nav1.3 expressed in Xenopus oocytes. Methods...
关键词：VGSC subtype Nav1.3 VGSC site 4-specific modulator BmKAS 
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