Acknowledgments We are grateful to Dr U Klingmuller (German Cancer Research Center, Germany) for providing the ErGFPcre mice; Dr J Han (Univiersity of Xiamen, China) for providing the p38ct wild-type and AF mutant plasmids; V Komnenovic (IMP, Austria) for histological analyses; and G Litos and M Kerenyi for technical support. We thank L Bakiri for critical reading of the manuscript. The IMP is funded by Boehringer Ingelheim. Work in LH laboratory is funded by the National Natural Science Foundation of China (30623003, 31071238), Shanghai Pujiang Program (09P J1411200) and the Knowledge Innovation Program of Shanghai Institutes for Biological Sciences (2009KIP101). Work in EFW laboratory is supported by a grant from F-BBVA and an ERC-Advanced grant ERC-FCK/2008/37.
Enucleation of erythroblasts during terminal differentiation is unique to mammals. Although erythroid enucleation has been extensively studied, only a few genes, including retinoblastoma protein (Rb), have been iden...