supported partly by Shanghai Pujiang Talent Project (No.:08PJ14017);the National Natural Science Foundation of China (Nos.:20771029 and 91013001);Shanghai Leading Academic Discipline Project (No. B108)
Soluble guanylate cyclase(sGC) is a critical heme-containing enzyme involved in NO signaling.The dimerization of sGC subunits is necessary for its bioactivity and its mechanism is a striking and an indistinct issue....