Supported by the National Key Basic Research Program (Grant No. 2002CB513100);the National Natural Science Foundation of China (Grant Nos. 20505007 and 20475015);the Key Project of Hunan Province Technology Plan of China (Grant Nos. 02JEY2004 and 0399Y1006)
This paper reports a new approach to detect ribozyme cleavage product based on the molecular-beacon-ligation system. The molecular beacon, designed in such a way that one-half of its loop is complementary to ribozyme ...