Project supported by the National Natural Science Foundation of China, the Personnel Department of China, Sciences and Technology Committee ofChongqing as well as the Foundation for Foreign Scientists from the Ministry of Spanish Culture and Education (No.SB9751204311).
A series of novel histidine-based open-chain dipeptides, polypeptides and cyclopeptides with anti-HIV potential were designed and synthesized from commercial histidine (Scheme 1).……