supported by grants from 973 Projectsfrom Ministry of Science and Technology of China (No.2010CB912800, 2011CB504203, 2009CB521706);A3 program of Natural Science Foundation of China(30921140312);the Natural Science Foundation of China(No. 30831160515, 30830110, 30973396, 81102023);Clinical Key Project of Public Health Administration ofChina, and Natural Science Foundation of GuangdongProvince (No. 8251008901000011, S2011040004481);Key Laboratory of Malignant Tumor Gene Regulation andTarget Therapy of Guangdong Higher EducationInstitutes, Sun Yat-sen University (No. KLB09001)
Metastasis is a multistep process involving modification of morphology to suit migration, reduction of tumor cell adhesion to the extracellular matrix, increase of cell mobility, tumor cell resistance to anoikis, and ...