国家自然科学基金(30973297)

作品数：4被引量：17H指数：2
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相关作者：董梅沈玉莲李国红刘爱清更多>>
相关机构：滨州市人民医院更多>>
相关期刊：《中华医院感染学杂志》《Frontiers of Medicine》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
相关主题：病原菌LOGISTIC回归分析先天性耳前瘘管术后感染INDUCIBLE更多>>
相关领域：医药卫生生物学更多>>
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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice被引量：1
《Frontiers of Medicine》2016年第4期481-489,共9页Yuqin Men Aizhen Zhang Liwen Zhang Yecheng Jin Zhishuo Wang Jing Zhao Xiaolin Yu Jian Zhang Jiangang Gao 
This work was supported by grants from the National Basic Research Program （973） of China （No. 2014CB541703）; the National Natural Science Foundation of China （Nos. 30871436, 30973297, 31171194, and 81670943）; the Shandong Provincial Science and Technology Key Program （No. 2009GG10002039）; and the Shandong Provincial Natural Science Foundation of China Grant （No. ZR2013CQ041）.
The tumor suppressor gene liver kinase B1 （LKB1）, also called STKll, encodes a serine/threonine kinase. LKB1 plays crucial roles in cell differentiation, proliferation, and polarity. In this study, LKB1 conditional ...
关键词：LKB1 stereociliary bundles kinocilium planar cell polarity HEARING MICE 
先天性耳前瘘管术后感染危险因素logistic回归分析被引量：8
《中华医院感染学杂志》2016年第7期1603-1605,共3页刘爱清 沈玉莲 李国红 董梅 崔方勇 
国家自然科学基金资助项目(30973297)
目的探讨干预措施对先天性耳前瘘管术后感染影响与相关危险因素,为降低先天性耳前瘘管术后感染提供参考依据。方法收集2010年1月-2014年12月医院收治的900例先天性耳前瘘管行手术治疗患者为研究对象,随机分为对照组和干预组,各450例,对...
关键词：先天性耳前瘘管 感染 病原菌 危险因素 
Induced pluripotent stem cells:origins, applications, and future perspectives被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第12期1059-1069,共11页Jing ZHAO Wen-jie JIANG Chen SUN Cong-zhe HOU Xiao-mei YANG Jian-gang GAO 
supported by the National Natural Science Foundation of China(Nos.30871436,30973297,31171194,and 31271534);the National Basic Research Program(973)of China(Nos.2010CB945002 and 2014CB541703);the Shandong Provincial Science and Technology Key Program(No.2009GG10003039);the Independent Development Foundation of Shandong University(Nos.2012JC019 and 2012ZD030),China
Embryonic stem(ES)cells are widely used for different purposes,including gene targeting,cell therapy,tissue repair,organ regeneration,and so on.However,studies and applications of ES cells are hindered by ethical issu...
关键词：Induced pluripotent stem cells ORIGIN Peripheral blood cells APPLICATION Potential issues 
Conditional gene manipulation:Cre-ating a new biological era被引量：7
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2012年第7期511-524,共14页Jian ZHANG Jing ZHAO Wen-jie JIANG Xi-wei SHAN Xiao-mei YANG Jian-gang GAO 
Project supported by the National Natural Science Foundation of China(Nos.30871436,30973297,and 31171194);the National Basic Research Program(973)of China(No.2010CB945002);the Ministry of Education of China(No.200804220011);Shandong Provincial Science and Technology Key Program(No.2009GG10003039),China
To solve the problem of embryonic lethality in conventional gene knockouts, site-specific recombinase （SSR） systems （Cre-loxP, FIp-FRT, and φC31） have been used for tissue-specific gene knockout. With the combina...
关键词：Site-specific recombinase Gene targeting Gene trapping Inducible systems φC31 system 
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