国家自然科学基金(30630039)

作品数：5被引量：3H指数：1
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相关作者：裴端卿郭允倩陈默马天骅饶艳华更多>>
相关机构：北京林业大学中国科学院广州生物医药与健康研究院清华大学更多>>
相关期刊：《Science Bulletin》《中国生物工程杂志》更多>>
相关主题：转录活性NANOGES细胞P300转录激活活性更多>>
相关领域：生物学农业科学更多>>
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p300通过homeobox结构域增强Nanog的转录激活活性被引量：2
《中国生物工程杂志》2009年第10期1-5,共5页郭允倩 陈默 马天骅 裴端卿 
国家自然科学基金(30725012,30630039,90813033);中国科学院知识创新工程(KSCX2-YW-R-48)资助项目
胚胎干细胞(ES细胞)能够不断地进行自我更新来维持其多能性,很多转录因子共同调控着ES细胞的自我更新和多能性,Nanog就是其中之一,然而Nanog维持ES细胞多能性的机制并不清楚。p300是真核生物中普遍存在的转录辅助因子,与许多转录因子共...
关键词：ES细胞 NANOG P300 homeobox结构域 转录活性 
Rex-1对Oct4转录活性的调控
《中国生物工程杂志》2009年第9期17-21,共5页郭允倩 饶艳华 赵元 裴端卿 
国家自然科学基金(30725012,30630039和90813033);中国科学院知识创新工程(KSCX2-YW-R-48)资助项目
Rex-1和Oct4是在多能性细胞中特异表达的转录因子,而Rex-1的生物学功能及其调控胚胎干细胞(ES细胞)多能性和分化能力的机制尚不清楚。实验探讨了Rex-1和Oct4的相互关系,利用免疫荧光实验和免疫共沉淀实验证明了Rex-1和Oct4两种蛋白共同...
关键词：ES细胞 转录因子 Rex-1 OCT4 
The N-terminal domain is a transcriptional activation domain required for Nanog to maintain ES cell self-renewal
《Chinese Science Bulletin》2009年第18期3271-3277,共7页GUO YunQian ZHANG Juan YE Li CHEN Mo YAO Dong PAN GuangJin ZHANG JieQiong PEI DuanQing 
Supported by the National Natural Science Foundation of China (Grant Nos. 30725012, 30630039 and 90813033);Knowledge Innovation Project of Chinese Academy of Sciences (Grant No. KSCX2-YW-R-48);Guangzhou Science and Technology Commission Foundation (Grant No. 2008A1-E4011);National Key Basic Research and Development Program of China (Grant Nos. 2006CB701504, 2006CB943600, 2007CB948002 and 2007CB947804);Beijing Forestry University Young Scientist Fund (Grant No. Blx2w8003)
Nanog is a transcription factor identified by its ability to maintain the self-renewal of ES cells in the absence of leukemia inhibitory factor (LIF). Nanog protein contains an N-terminal domain (ND), a DNA-binding ho...
关键词：NANOG 胚胎干细胞 转录激活 结构域 白血病抑制因子 转录因子 细胞重建 转录活性 
Mutations of nuclear localization signals in mNANOG generate dominant negative mutants
《Chinese Science Bulletin》2009年第8期1361-1368,共8页ZHANG Juan ZHANG XiaoFei PEI DuanQing 
Supported by National Natural Science Foundation of China (Grant Nos.30725012,30630039 and 90813033);Knowledge Innovation Project of Chinese Academy of Sciences (Grant No.KSCX2-YW-R-48);Guangzhou Science and Technology Commission Foundation (Grant No.2008A1-E4011);National Key Basic Research and Development Program of China (Grant Nos.2006CB701504,2006CB943600,2007CB948002 and 2007CB947804)
Mouse NANOG plays a critical role in maintaining self-renewal and pluripotency of embryonic stem cells.Yet,the precise mechanism of how mNANOG functions is still less known.Here,we report that mouse NANOG has two nucl...
关键词：核定位信号 突变体 显性 NANOG 突变小鼠 胚胎干细胞 转录活性 职能作用 
Induced pluripotent stem cell (iPS) technology:promises and challenges被引量：1
《Chinese Science Bulletin》2009年第1期2-8,共7页MIGUEL A Esteban 
Supported by the National Nature Science Foundation of China (Grant Nos. 30725012,30630039 and 90813033);Knowledge Innovation Project of Chinese Academy of Sciences (Grant No.KSCX2-YW-R-48);National Key Basic Research and Development Program of China (Grant Nos. 2006CB701504,2006CB943600,2007CB948002,2007CB947804.2007CB947900);Guangzhou Science and Technology Development Funds (Grant No.2008A1-E4011)
In 2006,an article published in Cell by Shinya Yamanaka took by surprise the stem cell research community. By performing systematic retroviral transduction of factors enriched in embryonic stem (ES) cells,the authors ...
关键词：自身更新 多能性 胚胎干细胞 多能干细胞 
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