GLOBIN

作品数：52被引量：68H指数：4
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相关领域：医药卫生更多>>
相关作者：李承军黄有文王荣新邱长春陈朝更多>>
相关机构：南京大学教育部华侨大学北京协和医学院更多>>
相关期刊：《Chinese Medical Sciences Journal》《Progress in Natural Science:Materials International》《Chinese Journal of Chemistry》《生物工程学报》更多>>
相关基金：国家自然科学基金更多>>
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Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies被引量：18
《Cell Research》2020年第3期276-278,共3页Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li 
partially supported by grants from the National Key R&D Program of China(2019YFA0110802,2019YFA0802800);Major Science and Technology Program of Hainan Province(ZDKJ2017007);the National Natural Science Foundation of China(81670470,81873685);grants from the Shanghai Municipal Commission for Science and Technology(18411953500);the Innovation program of Shanghai Municipal Education Commission(2019-01-07-00-05-E00054);the Fundamental Research Funds for the Central Universities.
Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient ...
关键词：IMPAIRED FETAL ANEMIA 
PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly被引量：1
《Cell Research》2017年第5期688-704,共17页Lena Ilan Farhat Osman Lise Sarah Namer Einav Eliahu Smadar Cohen-Chalamish Yitzhak Ben-Asouli Yona Banai Raymond Kaempfer 
Short elements in mammalian mRNA can control gene expression by activating the RNA-dependent protein kinase PKR that attenuates translation by phosphorylating cytoplasmic eukaryotic initiation factor 2a （eIF2α）. We...
关键词：globin mRNA splicing eIF2α phosphorylation PKR RNA activator of PKR spliceosome assembly 
Chromatin-binding in vivo of the erythroid kruppel-like factor,EKLF,in the murine globin loci被引量：2
《Cell Research》2006年第4期347-355,共9页Yu-Chiau Shyu Shau-Ching Wen Tung-Liang Lee Xin Chen Chia-Tse Hsu Hsin Chen Ruei-Lin Chen Jau-Lang Hwang Che-Kun James Shen 
EKLF is an erythroid-specific, zinc finger-containing transcription factor essential for the activation of the mammalian beta globin gene in erythroid cells of definitive lineage. We have prepared a polyclonal anti-mo...
关键词：EKLF murine globin gene clusters chromatin-immunoprecipitation （CHIP） chromosome structure 
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