FMOC

作品数：71被引量：205H指数：9
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Fmoc-protected amino acids as luminescent and circularly polarized luminescence materials based on charge transfer interaction被引量：1
《Chinese Chemical Letters》2022年第11期4918-4923,共6页Yiran Xia Aiyou Hao Pengyao Xing 
supported by the Qilu Young Scholarship Funding of Shandong University;supported by the National Natural Science Foundation of China(Nos.21901145,22171165);Natural Science Foundation of Jiangsu Province(No.BK20190209);the financial support from Youth cross-scientific innovation group of Shandong University(No.2020QNQT003)。
Fluorenylmethyloxycarbonyl(Fmoc)-protected amino acids are effective building blocks in self-assembled architectures at hierarchical levels,which however show limited luminescent properties and chiroptical activities....
关键词：Fmoc-amino acids Charge-transfer interaction Supramolecular chirality Multiple component coassembly 
Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide被引量：1
《Chinese Chemical Letters》2018年第7期1135-1138,共4页Chenchen Chen Shuai Gao Qian Qu Pengcheng Mi Anjin Tao Yi-Ming Li 
supported by the National Natural Science Foundation of China (NSFC No. 21572043);the Fundamental Research Funds for the Central Universities (No. PA2017GDQT0021)
Guanylate cyclase C(GC-C) is an important receptor protein expressed by intestinal epithelial cells, and its dysregulation leads to severe intestinal diseases. Linaclotide is a 14-amino acid peptide approved by the FD...
关键词：Linaclotide Guanylyl cyclase Protein chemical synthesis Fmoc solid phase peptide synthesis Racemic crystallization 
Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics被引量：1
《Chinese Chemical Letters》2015年第8期922-930,共9页Guang-Zong Tian Xiao-Li Wang Jing Hu Xue-Bin Wang Xiao-Qiang Guo Jian Yin 
supported by the National Science Foundation for Young Scientists of China(No.21302068);the Natural Science Foundation of Jiangsu Province,China(No.BK20130127);Jiangsu Province‘‘Six Summit Talent’’Foundation(No.2012-SWYY-009);the Specialized Research Fund for the Doctoral Program of Higher Education(No.20120093120002);the Fundamental Research Funds for the Central Universities(Nos.JUSRP51319B,JUSRP51411B)
In order to meet the increasing demands for the development of large varieties of new molecules for discovering new drugs and materials, organic chemists are developing many novel multifunctional building blocks, whic...
关键词：structurally carboxylic oligomer blocks assembled Fmoc amide carbohydrate diverse protected 
A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation
《Chinese Chemical Letters》2015年第8期946-950,共5页Jian Lu Xiao-Bo Tian Wei Huang 
supported by the National Natural Science Foundation of China(NNSFC,No.21372238);National 1000-Young-Talent Program of China;Shanghai Pujiang Talent Program(No.13PJ1410200)
Here, we report a new strategy for rapid synthesis of branched peptide by side-chain hydrazide ligation at Asn. The hydrazide was converted to thioester at Asn side chain by Na NO2 and thiol reagent, and sequential li...
关键词：ligation branched sequential reagent disulfide thiol Fmoc retention azide simultaneous 
Design, synthesis and anti-proliferative effects in tumor cells of new combretastatin A-4 analogs被引量：3
《Chinese Chemical Letters》2015年第8期993-999,共7页Lei Zhao Jiu-Jiu Zhou Xin-Ying Huang Li-Ping Cheng Wan Pang Zhen-Peng Kai Fan-Hong Wu 
supported by the National Natural Science Foundation of China(Nos.21472126,21402122);Shanghai Municipal Natural Science Foundation(No.12ZR450200)
A total of 11 novel combretastatin A-4（CA-4） analogs were designed, synthesized, and evaluated for the anti-proliferative effects in tumor cells. The compounds represent four structural classes：（i）hydrogenated de...
关键词：analogs proliferative potent structurally completion afford Fmoc solubility cytotoxicity dissolved 
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