supported by JSPS KAKENHI(No.21K06192 to S.Y.and 17H03584,18K19484,and 20H03519 to K.Y.);the Jikei University Research Fund(to K.Y.);the Takeda Science Foundation(to S.Y.);the Uehara Memorial Foundation(to S.Y.and K.Y.).
The dual-specificity tyrosine-regulated kinase (DYRK) family is evolutionarily conserved from invertebrate to mammals. DYRKs regulate cell proliferation, apoptosis, survival, and differentiation by modifying the prote...