KNOCK-IN

作品数:26被引量:105H指数:5
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相关领域:生物学医药卫生更多>>
相关作者:王红胡静姜元于翠娟吴智群更多>>
相关机构:吉林大学陕西师范大学广西大学国立中兴大学更多>>
相关期刊:《Journal of Integrative Agriculture》《Translational Neurodegeneration》《Genomics, Proteomics & Bioinformatics》《Neuroscience Bulletin》更多>>
相关基金:国家自然科学基金中国博士后科学基金广东省自然科学基金北京市自然科学基金更多>>
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Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression被引量:5
《Science China(Life Sciences)》2022年第11期2269-2286,共18页Qin Jin Xiaoyu Yang Shixue Gou Xiaoyi Liu Zhenpeng Zhuang Yanhui Liang Hui Shi Jiayuan Huang Han Wu Yu Zhao Zhen Ouyang Quanjun Zhang Zhaoming Liu Fangbing Chen Weikai Ge Jingke Xie Nan Li Chengdan Lai Xiaozhu Zhao Jiaowei Wang Meng Lian Lei Li Longquan Quan Yinghua Ye Liangxue Lai Kepin Wang 
the National Key Research and Development Program of China(2017YFA0105103,2021YFA0805903);the National Natural Science Foundation of China(81941004,32170542);2020 Research Program of Sanya Yazhou Bay Science and Technology City(202002011);Major Science and Technology Projects of Hainan Province(ZDKJ2021030);Key Research&Development Program of Hainan Province(ZDYF2021SHFZ052);Youth Innovation Promotion Association of the Chinese Academy of Sciences(2019347);Young Elite Scientist Sponsorship Program by CAST(YESS20200024);Biological Resources Progaramme,Chinese Academy of Sciences(KFJBRP-017-57);Key Research&Development Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110104004);China Postdoctoral Science Foundation(2020M682943);Science and Technology Planning Project of Guangdong Province,China(2019A030317010,2020B1212060052,2021B1212040016,2021A1515011110);Science and Technology Program of Guangzhou,China(202007030003);Research Unit of Generation of Large Animal Disease Models,Chinese Academy of Medical Sciences(2019-I2M-5-025)。
Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process.Binary Tet-On system has been widely employed to regulate transgenic expression by doxycycline.Previous...
关键词:double knock-in Tet-On system phiC31-mediated cassette exchange pig model hKRASG12D-related tumorigenesis 
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