the National Natural Science Foundation of China(81871222,81570763,and 81270947 to XQX);the Fundamental Science and Advanced Technology Research of Chongqing(Major Project,CSTC2015jcyjB0146);the National Program on Key Basic Research Project of China(973 Program,2012CB517505,to XQX).
Type 2 diabetes(T2D)and Alzheimer’s disease(AD)share several common pathophysiological features.Huperzine A(Hup A),a Lycopodium alkaloid extracted from the Chinese herb moss Huperzia serrata,is a specific and reversi...