POSTZYGOTIC

作品数：8被引量：10H指数：2
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相关领域：生物学农业科学更多>>
相关作者：魏丽萍更多>>
相关机构：北京大学更多>>
相关期刊：《Genomics, Proteomics & Bioinformatics》《Science Bulletin》《Horticulture Research》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
相关基金：国家重点基础研究发展计划国家自然科学基金高等学校学科创新引智计划更多>>
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Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals被引量：2
《Cell Research》2014年第11期1311-1327,共17页August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei 
Acknowledgments We are grateful to Drs Manyuan Long, Cheng Li, Jian Lu, and Jinzhu Jia for their valuable comments and suggestions. We thank Ms Sasha Sa for manuscript editing. We thank Xianing Zheng and Zhe Yu for assistance with validation. This work was supported by the National Natural Science Foundation of China （31025014 and 81171221） and the Ministry of Science and Technology of China （2012CB837600）. Publication charges were paid by the 111 project of the Ministry of Education of China.
Postzygotic single-nucleotide mutations （pSNMs） have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkable indi...
关键词：single-nucleotide mutation postzygotic mosaicism Dravet syndrome next-generation sequencing Bayesian model 
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