POSTZYGOTIC

作品数：8被引量：10H指数：2
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相关领域：生物学农业科学更多>>
相关作者：魏丽萍更多>>
相关机构：北京大学更多>>
相关期刊：《Genomics, Proteomics & Bioinformatics》《Science Bulletin》《Horticulture Research》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
相关基金：国家重点基础研究发展计划国家自然科学基金高等学校学科创新引智计划更多>>
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Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia
《Genomics, Proteomics & Bioinformatics》2022年第1期177-191,共15页Yaqiang Hong Dake Zhang Xiangtian Zhou Aili Chen Amir Abliz Jian Bai Liang Wang Qingtao Hu Kenan Gong Xiaonan Guan Mengfei Liu Xinchang Zheng Shujuan Lai Hongzhu Qu Fuxin Zhao Shuang Hao Zhen Wu Hong Cai Shaoyan Hu Yue Ma Junting Zhang Yang Ke Qian-Fei Wang Wei Chen Changqing Zeng 
supported by the grants from the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB13020500);the National Natural Science Foundation of China(NSFC)(Grant Nos.91131905,31471199,and 91631304);the Key Research Program of Chinese Academy of Sciences(Grant No.KJZD-EW-L14 to CZ);the NSFC(Grant Nos.31440057 and 31701081 to WC);the 111 Project(Grant No.B13003 to WC and DZ);the Innovation Promotion Association of Chinese Academy of Sciences(Grant Nos.2016098 to DZ and 2019103 to AC)。
Postzygotic mutations are acquired in normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenic factors.Here,we investigated postzygotic mutation spectra of healthy individuals using...
关键词：Postzygotic mutation Mutational signature Healthy individual Embryonic development HYPOXIA 
MosaicBase:A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Disease-related and Healthy Human Individuals被引量：2
《Genomics, Proteomics & Bioinformatics》2020年第2期140-149,共10页Xiaoxu Yang Changhong Yang Xianing Zheng Luoxing Xiong Yutian Tao Meng Wang Adam Yongxin Ye Qixi Wu Yanmei Dou Junyu Luo Liping Wei August Yue Huang 
supported by grants from the National Natural Science Foundation of China(Grant No.31530092);the Ministry of Science and Technology of China(Grant No.2015AA020108)awarded to LW
Mosaic variants resulting from postzygotic mutations are prevalent in the human genome and play important roles in human diseases.However,except for cancer-related variants,there is no collection of postzygotic mosaic...
关键词：POSTZYGOTIC MOSAICISM Noncancer Mutation MosaicBase 
Experimental hybridization and reproductive isolation between two sympatric species of tephritid fruit flies in the Anastrepha fraterculus species group
《Insect Science》2018年第6期1045-1055,共11页Juan Rull Eduardo Tadeo Rodrigo Lasa Christian L.Rodriguez Alma Altuzar-Molina Martin Aluja 
Among tephritid fruit flies,hybridization has been found to produce local adaptation and speciation,and in the case of pest species,induce behavioral and ecological alterations that can adversely impact efficient pest...
关键词：Anastrephafraterculus ANASTREPHA obliqua Haldane's RULE INTROGRESSION prezygotic ISOLATION POSTZYGOTIC ISOLATION 
Postzygotic mosaic mutations in autism spectrum disorder and other neuropsychiatric disorders
《Science Bulletin》2017年第24期1624-1625,共2页Longze Sha Qi Xu 
Autism, or autism spectrum disorder （ASD）, refers to a range of neurodevelopmental disorders characterized by： （1） impaired social interaction, （2） impaired verbal and non-verbal communication, and （3） restri...
关键词：Postzygotic mosaic mutations autism spectrum disorder other neuropsychiatric disorders 
Genome mapping of postzygotic hybrid necrosis in an interspecific pear population被引量：1
《Horticulture Research》2016年第1期326-337,共12页Sara Montanari Lester Brewer Robert Lamberts Riccardo Velasco Mickael Malnoy Laure Perchepied Philippe Guérif Charles-Eric Durel Vincent G M Bus Susan E Gardiner David Chagné 
SM was funded by the Fondazione Edmund Mach PhD School.
Deleterious epistatic interactions in plant inter-and intraspecific hybrids can cause a phenomenon known as hybrid necrosis,characterized by a typical seedling phenotype whose main distinguishing features are dwarfism...
关键词：breeding SEEDLING DWARF 
An Epigenetic Role for Disrupted Paternal Gene Expression in Postzygotic Seed Abortion in Arabidopsis Interspecific Hybrids被引量：5
《Molecular Plant》2015年第12期1766-1775,共10页Ryan C. Kirkbride Helen Hong Yu Gyoungju Nah Changqing Zhang Xiaoli Shi Z. Jeffrey Chen 
Interspecific hybrids often increase the levels of heterozygosity and hybrid vigor, but some interspecific hybrid seeds are aborted shortly after fertilization. The mechanism behind this postzygotic seed abortion is p...
关键词：epigenetics IMPRINTING paternal gene expression POLYPLOIDY hybrid incompatibility seeddevelopment 
Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals被引量：2
《Cell Research》2014年第11期1311-1327,共17页August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei 
Acknowledgments We are grateful to Drs Manyuan Long, Cheng Li, Jian Lu, and Jinzhu Jia for their valuable comments and suggestions. We thank Ms Sasha Sa for manuscript editing. We thank Xianing Zheng and Zhe Yu for assistance with validation. This work was supported by the National Natural Science Foundation of China （31025014 and 81171221） and the Ministry of Science and Technology of China （2012CB837600）. Publication charges were paid by the 111 project of the Ministry of Education of China.
Postzygotic single-nucleotide mutations （pSNMs） have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkable indi...
关键词：single-nucleotide mutation postzygotic mosaicism Dravet syndrome next-generation sequencing Bayesian model 
Absence of postzygotic isolating mechanisms:evidence from experimental hybridization between two species of tropical sea urchins
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2012年第10期797-810,共14页M.Aminur RAHMAN Tsuyoshi UEHARA Aziz ARSHAD Fatimah Md.YUSOFF Mariana Nor SHAMSUDIN 
Project supported by the Japan Society for the Promotion of Science (JSPS);the Research University Grant Scheme (RUGS) of Universiti Putra Malaysia (UPM) Vide Project (No. 05-03-10-1034RU)
Two reef margin species of tropical sea urchins,Echinometra sp.C(Ec) and Echinometra oblonga(Eo),occur sympatrically on Okinawa intertidal reefs in southern Japan.Hybridization between these species was examined throu...
关键词：Sea urchins Echinometra HYBRIDIZATION Gamete compatibility Reproductive isolation SPECIATION 
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