supported by the National Natural Science Foundation of China (No.30971319);the "Six Talent Peak" Project of Jiangsu Province (No.08-B);the grant from Open Project Program of the Key Disciplines of the Public Health Department of Jiangsu Province (No. XK13_200902)
Iptakalim is a new ATP-sensitive potassium (KATp) channel opener, and it inhibits the proliferation of pulmonary arterial smooth muscle cells (PASMCs) and pulmonary vascular remodeling. However, the underlying mec...