IPTAKALIM

作品数：23被引量：55H指数：4
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相关领域：医药卫生更多>>
相关作者：解卫平王虹李庆玲齐栩汪海更多>>
相关机构：南京医科大学江苏省人民医院军事医学科学院徐州市第一人民医院更多>>
相关期刊：《Acta Pharmacologica Sinica》《国际呼吸杂志》《Journal of Biomedical Research》《中国应用生理学杂志》更多>>
相关基金：国家自然科学基金江苏省自然科学基金基础研究重大项目前期研究专项国家教育部博士点基金更多>>
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Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction被引量：6
《Acta Pharmacologica Sinica》2022年第6期1349-1359,共11页Ruo-bing Guo Yin-feng Dong Zhi Yin Zhen-yu Cai Jin Yang Juan Ji Yu-qin Sun Xin-xin Huang Teng-fei Xue Hong Cheng Xi-qiao Zhou Xiu-lan Sun 
The National Natural Science Foundation of China(Nos.81973301,81773701,and 82003732);the Medical Research Project of Jiangsu Commission of Health(No.ZDA2020006);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.18KJA310004);the Major Project of Nanjing Medical University(No.NMUD2018008);the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Pericytes are present tight around the intervals of capillaries,play an essential role in stabilizing the blood-brain barrier,regulating blood flow and immunomodulation,and persistent contraction of pericytes eventual...
关键词：stroke cerebral ischemia IPTAKALIM ATP-sensitive potassium channels PERICYTES MICROCIRCULATION 
Pharmacological evidence： a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells被引量：2
《Acta Pharmacologica Sinica》2017年第1期41-55,共15页Shang WANG Chao-liang LONG Jun CHEN Wen-yu CUI Ya n-fang ZHANG Hao ZHANG Hai WANG 
Both iptakalim （Ipt） and natakalim （Nat） activate the SUR2B/Kir6.1 channel, an ATP-sensitive potassium channel （KATp） subtype, with high selectivity. In this study we investigated the therapeutic effects of Ipt ...
关键词：chronic heart failure ISOPROTERENOL IPTAKALIM natakalim GLIBENCLAMIDE ATP-sensitive potassium channel endothelialfunction eNOS/VASP pathways 
Iptakalim ameliorates relaxation to acetylcholine in thoracic aortic rings impaired by microvesicles derived from hypoxia/reoxygenation-treated HUVECs被引量：3
《中国应用生理学杂志》2016年第6期481-486,共6页Kun-wei ZHANG Shao-xun WANG Ye-yi LI Su WEI Man SHANG Chao LIU Miao LIU Yi-lu WANG Qian ZHU Yan-na WU Jun-qiu SONG Yan-xia LIU 
supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (20101202110005);the Natural Science Foundation of Tianjin (11JCZDJC18300);the Research Foundation of Tianjin Municipal Education Commission (20110106)
Objective: To investigate the effect of Iptakalim(Ipt) preventing injury of endothelial microvesicles(EMVs) derived from hypoxia/reoxygenation(H/R)-treated HUVECs on the relaxation of rat thoracic aortic rings and exp...
关键词：人脐静脉内皮细胞 主动脉 丝氨酸/苏氨酸激酶 复氧 缺氧 微泡 一氧化氮合酶 透射电子显微镜 
The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels被引量：3
《Acta Pharmacologica Sinica》2015年第12期1444-1450,共7页Su-yang WANG Wen-yu CUI Hai WANG 
Aim： To investigate the mechanisms underlying the activation of ATP-sensitive potassium channels （K-ATP） by iptakalim in cultured rat mesenteric microvascular endothelial cells （MVECs）. Methods： Whole-cell KATe ...
关键词：ATP-sensitive potassium channels microvascular endothelial cells IPTAKALIM PINACIDIL GLIBENCLAMIDE NUCLEOTIDES ATPyS automated patch clamp 
Synergisms of cardiovascular effects between iptakalim and amlodipine, hydrochlorothiazide or propranolol in anesthetized rats
《中国应用生理学杂志》2015年第6期532-540,共9页Hong-min ZHOU Ming-li ZHONG Ru-huan WANG Chao-liang LONG Yan-fang ZHANG Wen-yu CUI Hai WANG 
supported by grants from the State“973”Research Project(2012CB518200);State Key Project(AWS11J003)
The primary object of this fundamental research was to survey the synergistic cardiovascular effects of iptakalim, a novel ATP–sensitive potassium channel(KATP) opener, and clinical first-line antihypertensive drugs,...
关键词：氨氯地平 氢氯噻嗪 普萘洛尔 协同作用 心血管作用 大鼠 麻醉 ATP敏感钾通道 
The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function被引量：5
《Acta Pharmacologica Sinica》2011年第12期1466-1474,共9页Yu WANG Fu-hu ZENG Chao-liang LONG Zhi-yuan PAN Wen-yu CUI Ru-huan WANG Guo-shu LIU Hai WANG 
Aim： To investigate the effects of iptakalim on endothelial dysfunction induced by insulin resistance （IR） and to determine whether iptakalim improved IR associated with hypertension in fructose-fed rats （FFRs） a...
关键词：endothelial dysfunction insulin resistance HYPERTENSION ATP-sensitive potassium channel opener IPTAKALIM spontaneously hypertensive rats fructose-fed rats 
Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α被引量：6
《The Journal of Biomedical Research》2011年第6期392-401,共10页Xiangrong Zllo Feng Zong Hui Wang Qiang Wang Weiping Xie Hong Wang 
supported by the National Natural Science Foundation of China (No.30971319);the "Six Talent Peak" Project of Jiangsu Province (No.08-B);the grant from Open Project Program of the Key Disciplines of the Public Health Department of Jiangsu Province (No. XK13_200902)
Iptakalim is a new ATP-sensitive potassium （KATp） channel opener, and it inhibits the proliferation of pulmonary arterial smooth muscle cells （PASMCs） and pulmonary vascular remodeling. However, the underlying mec...
关键词：IPTAKALIM pulmonary arterial smooth muscle cells （PASMCs） pulmonary hypertension protein kinase C-α （PKC-α） hypoxia proliferation 
Iptakalim,an ATP-sensitive potassium channel opener,confers neuroprotection against cerebral ischemia/reperfusion injury in rats by protecting neurovascular unit cells被引量：9
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2011年第10期835-845,共11页Yu-hua RAN Hai WAN 
Objective:To investigate the role of iptakalim,an ATP-sensitive potassium channel opener,in transient cerebral ischemia/reperfusion (I/R) injury and its involved mechanisms.Methods:Intraluminal occlusion of middle cer...
关键词：Neurovascular unit Cerebral ischemia/reperfusion （I/R） injury ATP-sensitive potassium channel opener NEUROPROTECTION Apoptosis 
Association of the antihypertensive response of iptakalim with KCNJ11 （Kir6.2 gene） polymorphisms in Chinese Han hypertensive patients被引量：3
《Acta Pharmacologica Sinica》2011年第8期1078-1084,共7页Rui-feng DUAN Wen-yu CUI Hai WANG 
Aim： To study the relationship between the antihypertensive response of iptakalim and KCNJ11 polymorphisms in Chinese Han hypertensive patients. Methods： One hundred sixty two Chinese Hart hypertensive patients were...
关键词：KCNJ11 KIR6.2 GENOTYPE hypertension ATP-sensitive potassium channel opener IPTAKALIM POLYMORPHISMS systolic blood pressure diastolic blood pressure 
Chemerin/ChemR23 signaling axis is involved in the endothelial protection by KATP channel opener iptakalim被引量：4
《Acta Pharmacologica Sinica》2011年第5期573-580,共8页Rui-jun ZHAO Hai WANG 
Aim： To elucidate the modulation of the chemerin/ChemR23 axis by iptakalim-induced opening of KATP channels and to determine the role of the chemerin/ChemR23 axis in the iptakalim-mediated endothelial protection. Met...
关键词：ATP-sensitive potassium channel IPTAKALIM endothelial cells ChemR23 CHEMERIN NO 
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