Association of the antihypertensive response of iptakalim with KCNJ11 （Kir6.2 gene） polymorphisms in Chinese Han hypertensive patients  

作　　者：Rui-feng DUAN Wen-yu CUI Hai WANG 

机构地区：[1]Cardiovascular Drug Research Center, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Bei- jing 100850, China [2]Thadweik Academy of Medicine, Beijing 100039, China

出　　处：《Acta Pharmacologica Sinica》2011年第8期1078-1084,共7页中国药理学报（英文版）

摘　　要：Aim： To study the relationship between the antihypertensive response of iptakalim and KCNJ11 polymorphisms in Chinese Han hypertensive patients. Methods： One hundred sixty two Chinese Hart hypertensive patients were administered iptakalim （5 or 10 mg/d, po） for 8 weeks. Before the treatment and 24 h after completing the treatment blood pressure （BP） was measured. Genotyping was performed using direct sequencing. Results： Four common A190A, E23K, 1337V and 3＇UTR ＋62 G/A polymorphisms were found in KCNJ11. The E23K, 1337V and 3＇UTR ＋62 G/A polymorphisms were in complete linkage disequilibrium, and 1337V was used as a representative. There were no significant differences in age, body mass index, sex, baseline systolic BP （SBP） and diastolic BP （DBP） among the 3 genotypes for the four polymorphisms. Significant association was found between SBP response and the polymorphisms （adjusted regression coefficient： 3.5 [1.2] mmHg; P=0.003 for the A190A polymorphism; adjusted regression coefficient： 3.1 [1.2] mmHg; P=0.012 for the 1337V polymorphism）. The patients with TT genotype for A190A polymorphism had higher clinical efficacy than those with CC genotype. Conclusion： The results suggest the KCNJ11 polymorphisms are associated with the SBP-Iowering response of short-term iptakalim therapy in Chinese Han hypertensive patients.Aim： To study the relationship between the antihypertensive response of iptakalim and KCNJ11 polymorphisms in Chinese Han hypertensive patients. Methods： One hundred sixty two Chinese Hart hypertensive patients were administered iptakalim （5 or 10 mg/d, po） for 8 weeks. Before the treatment and 24 h after completing the treatment blood pressure （BP） was measured. Genotyping was performed using direct sequencing. Results： Four common A190A, E23K, 1337V and 3＇UTR ＋62 G/A polymorphisms were found in KCNJ11. The E23K, 1337V and 3＇UTR ＋62 G/A polymorphisms were in complete linkage disequilibrium, and 1337V was used as a representative. There were no significant differences in age, body mass index, sex, baseline systolic BP （SBP） and diastolic BP （DBP） among the 3 genotypes for the four polymorphisms. Significant association was found between SBP response and the polymorphisms （adjusted regression coefficient： 3.5 [1.2] mmHg; P=0.003 for the A190A polymorphism; adjusted regression coefficient： 3.1 [1.2] mmHg; P=0.012 for the 1337V polymorphism）. The patients with TT genotype for A190A polymorphism had higher clinical efficacy than those with CC genotype. Conclusion： The results suggest the KCNJ11 polymorphisms are associated with the SBP-Iowering response of short-term iptakalim therapy in Chinese Han hypertensive patients.

关 键 词：KCNJ11 KIR6.2 GENOTYPE hypertension ATP-sensitive potassium channel opener IPTAKALIM POLYMORPHISMS systolic blood pressure diastolic blood pressure 

分 类 号：Q347[生物学—遗传学] Q346.5