PINACIDIL

作品数：31被引量：56H指数：4
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相关领域：医药卫生更多>>
相关作者：宋治远仝识非叶英阳世光彭司勋更多>>
相关机构：中国药科大学遵义医学院第三军医大学西南医院武汉大学更多>>
相关期刊：《中华麻醉学杂志》《中国药学杂志》《中国药科大学学报》《Journal of Traditional Chinese Medicine》更多>>
相关基金：国家自然科学基金广西壮族自治区自然科学基金更多>>
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Therapeutic effects of a taurine-magnesium coordination compound on experimental models of type 2 short QT syndrome被引量：2
《Acta Pharmacologica Sinica》2018年第3期382-392,共11页Meng-yao AN Kai SUN Yan LI Ying-ying PAN Yong-qiang YIN Yi KANG Tao SUN Hong WU Wei-zhen GAO Jian-shi LOU 
The authors appreciate the valuable comments from other members of our laboratories. This study was supported by the National Natural Science Foundation of China （No 81373410） and the Youth Project of Tianjin Natural Foundation, China （No 14JCQNJC13700）.
Short QT syndrome （SQTS） is a genetic arrhythmogenic disease that can cause malignant arrhythmia and sudden cardiac death. The current therapies for SQTS have application restrictions. We previously found that Mg- ...
关键词：short QT syndrome taurine-magnesium coordination compound PINACIDIL TRAPIDIL Langendorff guinea pig-perfused hearts ventricular myocytes IKS refractory period 
The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels被引量：3
《Acta Pharmacologica Sinica》2015年第12期1444-1450,共7页Su-yang WANG Wen-yu CUI Hai WANG 
Aim： To investigate the mechanisms underlying the activation of ATP-sensitive potassium channels （K-ATP） by iptakalim in cultured rat mesenteric microvascular endothelial cells （MVECs）. Methods： Whole-cell KATe ...
关键词：ATP-sensitive potassium channels microvascular endothelial cells IPTAKALIM PINACIDIL GLIBENCLAMIDE NUCLEOTIDES ATPyS automated patch clamp 
The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts
《Acta Pharmacologica Sinica》2012年第12期1488-1494,共7页Qi JIN Ning ZHANG Jian ZHOU Chang-jian LIN Yang PANG Gang GU Wei-feng SHEN Li-qun WU 
Aim： To determine the postshock activation patterns with both successful and failed shocks in a canine model of ventricular fibrillation and whether piniacidil, an early after-depolarization （EAD） inhibitor, altere...
关键词：PINACIDIL heart ventricular fibrillation early after-depolarization （EAD） defibrillation threshold postshock activation 
Pinacidil,a K_(atp) channel opener,identified as a novel agonist for TRPA1被引量：1
《Chinese Science Bulletin》2012年第15期1810-1817,共8页MA LiangHui DENG Ying ZHANG Bi BAI YanQiu CAO Jing LI ShiYou LIU JianFeng 
supported by grants from the Ministry of Science and Technology (2007CB914200 and 2010DFA32140);the National Natural Science Foundation of China(31130028 and 30973514);Program of Introducing Talents of Discipline to Universities of Ministry of Education (B08029)
The transient receptor potential Ankyrin 1(TRPA1) cation channel is activated by various pungent and irritant compounds,and it also mediates the perception of noxious cold.Identification of different agonists for this...
关键词：ATP敏感性钾通道 受体激动剂 还原型谷胱甘肽 EC50值 激活机制 KATP通道 位点特异性 离子通道 
Protective effects of pinacidil hyperpolarizing cardioplegia on myocardial ischemia reperfusion injury by mitochondrial KATP channels被引量：11
《Chinese Medical Journal》2011年第24期4205-4210,共6页YU Tian FU Xiao-yun LIU Xing-kui YU Zhi-hao 
This project was supported by a grant from the National Natural Science Foundation of China （No. 30460132）.
Background Many studies have indicated that hyperpolarizing cardioplegia is responsible for myocardial preservation and researchers have suggested that the adenosine triphosphate-sensitive potassium channels （KATe） ...
关键词：cardioplegic solutions heart arrest PINACIDIL ischemia/reperfusion injury myocardial mitochondrial ultrastructure potassium channel blockers 
Astragaloside IV Regulates Expression of ATP-sensitive Potassium Channel Subunits after Ischemia-reperfusion in Rat Ventricular Cardiomyocytes被引量：9
《Journal of Traditional Chinese Medicine》2011年第4期321-326,共6页韩向晖 刘萍 章怡祎 张娜 陈富荣 蔡珏峰 
supported by Key Project of Shanghai Education Commission (No.07ZZ56);National Natural Science Foundation of China (No.30873340);National 11th-Five Year Research Program of China (No.2007BAI20B078);Program for Innovative Research Team in University of Shanghai Education Commission
Objective: Astragaloside IV (AsIV) is the major effective component extracted from the Chinese herb Astragalus membranaceus, which has been widely used to treat cardiovascular disease. Recent studies have shown that A...
关键词：Astragaloside IV pinacidil myocardial ischemia-reperfusion KATP channels 
Adenosine triphosphate-sensitive potassium channel opener protects PC12 cells against hypoxia-induced apoptosis through PI3K/Akt and Bcl-2 signaling pathways被引量：1
《Neural Regeneration Research》2010年第22期1706-1711,共6页Hong Zhang Chunhong Jia Danyang Zhao Yang Lu Runling Wang Jia Li 
the Natural Science Foundation of Liaoning Province,No.20052097,2008225010
Although previous studies have shown the neuroprotective effects of the adenosine triphosphate （ATP）-sensitive potassium （KATP） channel opener against ischemic neuronal damage, little is known about the mechanisms...
关键词：ATP-sensitive potassium channel PC12 cells HYPOXIA apoptosis PINACIDIL phosphatidylinositol-3 kinase/v-akt murine thymoma viral oncogene homolog BCL-2 
KATP通道开放剂Pinacidil诱导的超极化停搏对离体幼兔心肌的保护作用被引量：1
《中华实验外科杂志》2010年第9期1233-1235,共3页邓宏平 程邦昌 陈蕾 王志维 毛志福 胡小平 
目的 观察Pinacidil诱导的超极化停搏对离体幼兔心肌保护的效果.方法 建立幼兔离体心脏灌注模型,分别以10℃标准St.Thomas液（Ⅰ组）、含Pinacidil 50 μmol/L的10℃ St.Thomas液（K＋5 mmol/L、Ⅱ组）和含Pinacidil 50 μmol/L的37 ℃ ...
关键词：超极化停搏 未成熟心肌 心肌保护 
不同浓度Pinacidil对兔心室肌细胞电生理特性的影响
《长江大学学报（自科版）（下旬）》2010年第2期1-4,共4页王玉璟 黄从新 杨沙宁 金立军 杨学新 余兆新 彭水先 潘炎 
目的:通过观察不同浓度的ATP敏感性钾通道(KATP)开放剂Pinacidil对家兔心室肌细胞电生理特性的影响,从而间接了解它不同程度的激活是否引起电活动的不均一性。方法:取健康新西兰大耳白家兔25只,体质量1.25～1.75kg,肝素处理后按改良的Ta...
关键词：钾通道/三磷酸腺苷敏感性 心室肌 电生理 吡哪地尔 
不同器官保存液对停搏供心的保护被引量：1
《中国组织工程研究与临床康复》2008年第40期7817-7820,共4页胡英斌 周新民 李津 彭昊 胡野荣 
背景:有研究已经证实应用人停搏供心进行心脏移植可以取得与非停搏供心移植相同的效果,但如何对停搏供心进行处理使之达到或接近非停搏供心移植的效果是一个新的课题。目的:采用新西兰大白兔离体停搏供心模型,探讨3种不同的器官保存液Ce...
关键词：PINACIDIL Celsior UW 停搏供心 心肌保护 
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