the National Natural Science Foundation of China(Nos.21302071, 21261008, 21204031), the Natural Science Foundation of Jiangsu Province, China(No.BK20130484), the Scientific Research Foundation for Advanced Talents of Jiangsu University, China(No.12JDG089/14JDG054) and the Hainan International Science and Technology Cooperation, China (No.KJHZ2014-05).
Difluoromethylation of 2-hydroxychalcones using sodium 2-chloro-2,2-difluoroacetate as the difluoro- methylating agent was developed. Under facile conditions, a wide range of aryl difluoromethyl ethers were obtained i...