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Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation被引量：1
《Science China(Life Sciences)》2021年第12期2144-2152,共9页Peng Bai Qiuping Zhou Pengcheng Wei Hua Bai Sanny K.Chan John W.Kappler Philippa Marrack Lei Yin 
supported by the National Natural Science Foundation of China(31870728,31470738,and 32000611);the National Basic Research Program of China(2014CB910103);the Fundamental Research Funds for the Central Universities(2042020kfxg02);the China Postdoctoral Science Foundation(2018M642918)。
Cytotoxic T cells targeting cancer neoantigens harboring driver mutations can lead to durable tumor regression in an HLAIdependent manner.However,it is difficult to extend the population of patients who are eligible f...
关键词：cancer immunology major histocompatibility complex(MHC) vaccine neoantigen prediction antigen immunogenicity 
Identification of Klebsiella pneumoniae strains harboring inactive extended-spectrum beta-lactamase antibiotic-resistance genes被引量：4
《Chinese Medical Journal》2014年第17期3051-3057,共7页Xu Li Zhai Yao Lyu Yuan Wang Qi An Shuchang Chen Jichao Chen Yusheng Liu Lin Li Jiabin Gao Zhancheng 
Background The extended-spectrum beta-lactamase （ESBL）-producing Klebsiella pneumoniae has increasingly become a major contributor to nosocomial infections and can exhibit multiple antibiotic resistance.Previous stu...
关键词：Klebsiella pneumoniae extended-spectrum beta-lactamase gene silencing beta-lactam resistance promoter regions 
Acquisition of Insect-Resistant Transgenic Maize Harboring a Truncated cry1Ah Gene via Agrobacterium-Mediated Transformation被引量：6
《Journal of Integrative Agriculture》2014年第5期937-944,共8页LI Xiu-ying LANG Zhi-hong ZHANG Jie HE Kang-lai ZHU Li HUANG Da-fang 
the financial support of the Genetically Modified Organisms Breeding Major Project, China (2011ZX08003-001);the National Basic Research Program of China (973 Program, 2009CB118902);the National Natural Science Foundation of China (30970231)
A novel insecticidal gene crylAh was cloned from Bacillus thuringiensis isolate BT8 previously for plant genetic engineering improvement. Truncated active CrylAh toxin has a toxicity level similar to that of the full-...
关键词：Bacillus thuringiensis truncated crylAh gene insectresistant maize stable inheritance 
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