HARBORING

作品数：84被引量：159H指数：6
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相关领域：医药卫生农业科学更多>>
相关作者：张景昱叶梁宋艳茹王小桐更多>>
相关机构：中国科学院植物研究所南京军区南京总医院更多>>
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Expression and characterization of a novel GH128 laminarinase OUC-Bs Lam26 harboring both hydrolyzing and transferring activities
《Food Science and Human Wellness》2025年第1期134-143,共10页Yueyang Dong Yongyi Quan Hong Jiang Hamed I.Hamouda Zewei Lu Yimiao Chen Chengqiang Li Xiangzhao Mao 
supported by the National Natural Science Foundation of China(32072159);Natural Science Foundation of Hainan Province(322QN338);Young Talent of Lifting Engineering for Science and Technology in Shandong,China(SDAST2021qt18);Qingdao Science and Technology Plan Key Research and Development Project(22-3-3-hygg-28-hy);Fundamental Research Funds for the Central Universities(202262003);Taishan Scholar Project of Shandong Province(tsqn202312099);Support Program for Youth Innovation Technology in Colleges and Universities of Shandong Province(2023KJ041)。
Laminarin oligosaccharides(LOSs)with a specific degree of polymerization prepared through the laminarin degradation via laminarinase present more significant nutritional functions and application values.Human intestin...
关键词：Laminarinase EXPRESSION Laminarin oligosaccharides Hydrolytic pattern Novel glycosides 
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report
《Frontiers of Medicine》2025年第1期170-173,共4页Xiaotong Qiu Liangkun You Chongwei Wang Jin Sheng 
SMARCA4-deficient non small cell lung cancer (SMARCA4-dNSCLC) has recently garnered increasing attention due to its high malignancy and poor prognosis. The literature suggests that in non small cell lung cancer (NSCLC...
关键词：SMARCA4-dNSCLC rare EGFR mutations targeted therapy case report 
The core phoD-harboring bacteria promote wheat phosphorus uptake by enhancing alkaline phosphatase activity under long-term fertilization
《Soil Ecology Letters》2024年第4期163-173,共11页Shuobing He Yuying Ma Teng Yang Xiao Fu Li Nie Jiasui Li Daozhong Wang Yanhua Su Haiyan Chu 
supported by the National Natural Science Foundation of China(Grant No.42307402).
Soil pH was the key factor influencing the phoDharboring bacterial networks.Identification of a cluster positively linked to ALP activity and plant P uptake.Low soil pH resulted in a severe loss of phoDharboring bacte...
关键词：phoD-harboring bacteria co-occurrence network long-term fertilization wheat phosphorus uptake 
Emergence of Multidrug-Resistant Proteus mirabilis Harboring both blaNDM-1 and cfr genes
《Biomedical and Environmental Sciences》2024年第10期1208-1212,共5页Meiqing Sun Xiuhong Yang Beibei Miao Jingyi Zhang Shuang Meng Zhe Feng Juan Li 
the National Key Research and Development Program of China[grant number 2021YFC2302002]for financial support.
Proteus mirabilis is abundant in soil and water,and although it is part of the normal human intestinal flora(along with Klebsiella species and Escherichia coli),it is known to cause serious infections in humans,with a...
关键词：LIS Proteus ant 
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation被引量：1
《Frontiers of Medicine》2024年第5期831-849,共19页Shubei Chen Dianjia Liu Bingyi Chen Zijuan Li Binhe Chang Chunhui Xu Ningzhe Li Changzhou Feng Xibo Hu Weiying Wang Yuanliang Zhang Yinyin Xie Qiuhua Huang Yingcai Wang Stephen DNimer Saijuan Chen Zhu Chen Lan Wang Xiaojian Sun 
supported by the Center for High Performance Computing at Shanghai Jiao Tong University;supported by the National Key R&D Plan of China(No.2018YFA0107802 to Xiaojian Sun,Nos.2018YFA0107200 and 2018YFA0800203 to Lan Wang);the National Natural Science Foundation of China General Program(Nos.81970150 and 82170156 to Lan Wang);Shanghai“Science and Technology Innovation Action Plan”Excellent Academic/Technical Leader Program(Youth)(No.21XD1424500 to Lan Wang);Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01 to Saijuan Chen and Xiaojian Sun);Samuel Waxman Cancer Research Foundation,and the Shanghai Guangci Translational Medical Research Development Foundation.
SETD2 is the only enzyme responsible for transcription-coupled histone H3 lysine 36 trimethylation(H3K36me3).Mutations in SETD2 cause human diseases including cancer and developmental defects.In mice,Setd2 is essentia...
关键词：Setd2 H3K36 methylation EPIGENETICS embryonic development cancer 
Promoting the production of challenging proteins via induced expression in CHO cells and modified cell-free lysates harboring T7 RNA polymerase and mutant eIF2α
《Synthetic and Systems Biotechnology》2024年第3期416-424,共9页Jeffrey L.Schloßhauer Lena Tholen Alexander Korner Stefan Kubick Sofia Chatzopoulou Anja Honow Anne Zemella 
supported by the European Regional Development Fund(EFRE)and the German Ministry of Education and Research(BMBF 031B0831C).
Chinese hamster ovary(CHO)cells are crucial in biopharmaceutical production due to their scalability and capacity for human-like post-translational modifications.However,toxic proteins and membrane proteins are often ...
关键词：Inducible expression CHO cells Cell-free protein synthesis CRISPR T7 RNA polymerase eIF2 Rosa26 
Efficacy and Safety of Primary Radiotherapy in Combination with EGFR-TKIs for Non-Small Cell Lung Cancer Harboring EGFR Mutation
《Journal of Biosciences and Medicines》2024年第9期142-154,共13页Dongxu Ao Meng Wang Jinyuan Xie Yang Zhang Xinran Zhang Ya Shu Chenshi Lin Qingqing Ye 
Objective: To evaluate the efficacy and safety of EGFR-TKI with the radiotherapy in EGFR mutant metastatic NSCLC. Methods: Retrospective analysis of 72 patients with stage IV lung cancer with EGFR-sensitive mutation. ...
关键词：Non-Small Cell Lung Cancer Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor RADIOTHERAPY 
Generation of Eco-Friendly and Disease-Resistant Channel Catfish(Ictalurus punctatus)Harboring the Alligator Cathelicidin Gene via CRISPR/Cas9 Engineering
《Engineering》2024年第8期273-286,共14页Jinhai Wang Baofeng Su De Xing Timothy J.Bruce Shangjia Li Logan Bern Mei Shang Andrew Johnson Rhoda Mae C.Simora Michael Coogan Darshika U.Hettiarachchi Wenwen Wang Tasnuba Hasin Jacob Al-Armanazi Cuiyu Lu Rex A.Dunham 
supported by USDA Grant(2018-33522-28769);Alabama Agricultural Experiment Station grant(AAES-AIR).
As a precise and versatile tool for genome manipulation,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)platform holds promise for modifying fish traits of intere...
关键词：Genome editing ssODN DSDNA Antimicrobial peptide Reproductive confinement Aquaculture 
Characterization of a 4.1 Mb inversion harboring the stripe rust resistance gene YR86 on wheat chromosome 2AL
《The Crop Journal》2024年第4期1168-1175,共8页Qiang Cao Zhanwang Zhu Dengan Xu Jianhui Wu Xiaowan Xu Yan Dong Yingjie Bian Fugong Ding Dehui Zhao Yang Tu Ling Wu Dejun Han Caixia Lan Xianchun Xia Zhonghu He Yuanfeng Hao 
financially supported by the National Key Research and Development Program of China (2022YFD1200900 and 2022YFD1200904);the Agricultural Science and Technology Innovation Program;Fundamental Research Funds for Central NonProfit of Institute of Crop Sciences, CAAS;Shijiazhuang S&T Project (232490022A and 232490432A)
Wheat cultivar Zhongmai 895 was earlier found to carry YR86 in an 11.6 Mb recombination-suppressed region on chromosome 2AL when crossed with Yangmai 16.To fine-map the YR86 locus,we developed two large F2 populations...
关键词：Adult-plant resistance Chromosomal inversion Puccinia striiformis Triticum aestivum 
Platinum-based chemotherapy for metastatic insulinoma harboring germline mutation in DNA damage repair pathway:a case report
《Journal of Pancreatology》2024年第2期167-169,共3页Kaili Yang Hongyan Ying Mei Guan Lina Wang Jia Xu Yuejuan Cheng 
Malignant insulinomas are rare neuroendocrine tumors that require management for both symptomatic control and tumor reduction.It is clinically challenging to optimize treatment strategies for refractory malignant insu...
关键词：CHEMOTHERAPY DNA damage repair Germline mutation Malignant insulinoma 
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