ACYL-COA

作品数：24被引量：97H指数：6
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相关领域：医药卫生农业科学更多>>
相关作者：杨璞更多>>
相关机构：北京大学中国林业科学研究院资源昆虫研究所更多>>
相关期刊：《Science China(Life Sciences)》《Science China Chemistry》《World Journal of Gastroenterology》《World Journal of Clinical Cases》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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  • 期刊=Synthetic and Systems Biotechnologyx
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Enhanced triacylglycerol metabolism contributes to the efficient biosynthesis of spinosad in Saccharopolyspora spinosa
《Synthetic and Systems Biotechnology》2024年第4期809-819,共11页Li Cao Yangchun Liu Lin Sun Zirong Zhu Danlu Yang Ziyuan Xia Duo Jin Zirui Dai Jie Rang Liqiu Xia 
supported by funding from the National Natural Science Foundation of China(31770106,32200062);the Natural Science Foundation of Hunan Province(2024JJ5258).
Triacylglycerol(TAG)is crucial for antibiotic biosynthesis derived from Streptomyces,as it serves as an important carbon source.In this study,the supplementation of exogenous TAG led to a 3.92-fold augmentation in spi...
关键词：Saccharopolyspora spinosa SPINOSAD TRIACYLGLYCEROL LipaseAcyl-CoAs 
Enhancing the activity and succinyl-CoA specificity of 3-ketoacyl-CoA thiolase Tfu_0875 through rational binding pocket engineering
《Synthetic and Systems Biotechnology》2024年第3期558-568,共11页Lixia Liu Shuang Liu Xiangyang Hu Shenghu Zhou Yu Deng 
supported by the National Key R&D Program of China(2022YFC2104600);National Natural Science Foundation of China(22378170);the Distinguished Young Scholars of Jiangsu Province(BK20220089);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-015).
The 3-ketoacyl-CoA thiolase is the rate-limiting enzyme for linear dicarboxylic acids production.However,the promiscuous substrate specificity and suboptimal catalytic performance have restricted its application.Here ...
关键词：Adipic acid 3-Ketoacyl-CoA thiolase Claisen condensation Deep learning GRAPE strategy 
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