LIDAMYCIN

作品数：19被引量：65H指数：6
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相关领域：医药卫生更多>>
相关作者：刘芳陈淑珍商悦甄永苏吴淑英更多>>
相关机构：中国医学科学院北京协和医学院中国医学科学院中国协和医科大学清华大学更多>>
相关期刊：《Science Bulletin》《中国抗生素杂志》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家高技术研究发展计划国家自然科学基金国家重点基础研究发展计划更多>>
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Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin被引量：6
《Science China(Life Sciences)》2011年第3期255-262,共8页FANG Hong MIAO QingFang ZHANG ShengHua CHENG Xin XIONG DongSheng ZHEN YongSu 
supported by the National High Technology Research and Development Program of China(Grant No. 2006AA02A255);the National Natural Science Foundation of China(Grant No. 30701029);the National Science and Technology Major Projects(Grant Nos.2009ZX09103-720 and 2010ZX09401-407)
Antibody-based fusion proteins are the next generation of antibody therapies for cancer and other diseases.CD20 antigen,which is overexpressed on cell membranes in nearly 95% of cases of B-cell Non-Hodgkin's Lymphoma,...
关键词：LYMPHOMA CD20 LIDAMYCIN SCFV energized fusion protein 
Generation and antitumor effects of an engineered and energized fusion protein VL-LDP-AE composed of single-domain antibody and lidamycin被引量：3
《Science China(Life Sciences)》2007年第4期447-456,共10页MIAO QingFang, SHANG BoYang, OUYANG ZhiGang, LIU XiaoYun & ZHEN YongSu Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China 
Supported by the National High Technology Research and Development Program of China (863 Program)(Grant No. 2006AA02A255)
Type IV collagenase plays a pivotal role in invasion, metastasis and angiogenesis of tumor. Single domain antibodies are attractive as tumor-targeting vehicle because of their much smaller size com-pared with antibody...
关键词：type IV COLLAGENASE SINGLE-DOMAIN ANTIBODY LIDAMYCIN fusion protein antibody-based drugs 
Antitumor effects of the molecule-downsized immunocon-jugate composed of lidamycin and Fab' fragment of monoclonal antibody directed against type IV collagenase被引量：7
《Science China(Life Sciences)》2004年第1期66-73,共8页WANG Fengqiang SHANG Boyang ZHEN Yongsu 
Type IV collagenase plays an important role in tumor invasion and metastasis through cleaving type IV collagen in the basement membrane and extracellular matrix. In this study a molecule-downsized immunoconjugate (Fab...
关键词：anti-type IV COLLAGENASE MONOCLONAL antibody  immunoconjugate  lidamycin  antibody-based drug. 
Cloning,expression and characterization of gene sgcD involved in the biosynthesis of novel antitumor lidamycin
《Science China(Life Sciences)》2003年第3期310-319,共10页李敏 刘文 李元 
supported by the National Natural Science Foundation of China(Grant No.39870029).
Lidamycin with high antitumor activity is a novel enediyne antitumor antibiotic produced by Streptomyces globisporus C1027. The 75 kb biosynthesis gene cluster of lidamycin containing 33 open reading frames has been c...
关键词：Streptomyces  lidamycin  biosynthesis  gene disruption  aminomutase. 
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