supported by grants from "Significant new drug development" Science and Technology Major Projects of China (2009ZX09301-003; 2009ZX09401-005; 2010ZX09401-407)
Objective Lidamycin (LDM) can be dissociated to an apoprotein (LDP) and an active enediyne chromophore (AE). The detached AE can reassemble with its LDP-containing fusion protein to endow the latter with potent ...
supported by the National High Technology Research and Development Program of China(Grant No. 2006AA02A255);the National Natural Science Foundation of China(Grant No. 30701029);the National Science and Technology Major Projects(Grant Nos.2009ZX09103-720 and 2010ZX09401-407)
Antibody-based fusion proteins are the next generation of antibody therapies for cancer and other diseases.CD20 antigen,which is overexpressed on cell membranes in nearly 95% of cases of B-cell Non-Hodgkin's Lymphoma,...