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MDMX: 作品数：25被引量：50H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：苏正定成细瑶张华山陈蓉吴胤瑛更多>>; 相关机构：湖北工业大学天津医科大学烟台大学西安交通大学医学院第一附属医院更多>>; 相关期刊：《Frontiers of physics》《生命科学》《医学综述》《肿瘤预防与治疗》更多>>; 相关基金：国家自然科学基金陕西省自然科学基金上海市青年科技启明星计划甘肃省科技计划项目更多>>

应用pCMV3-MdmX-RFP表达载体建立H1299^(p53R^(2)13X/MdmX)稳转细胞系: 《生物技术》2023年第6期683-688,696,共7页周婷李丹王芮宋士奎柯志强苏正定; 湖北省教育厅科学研究计划指导性项目(B2021224)。; [目的]探索应用pCMV3-MdmX-RFP表达载体构建H1299^(p53R^(2)13X/MdmX)稳转细胞系。[方法]用KpnⅠ和NotⅠ双酶切后连接,构建pCMV3-MdmX-RFP表达载体并测序。重组质粒转染H1299p53R^(2)13X细胞,用100μg/mL的潮霉素B筛选2 w。将筛选出的...; 关键词：H1299 P53 MDMX G418 潮霉素B 稳转细胞系

Bicyclic stapled peptides based on p53 as dual inhibitors for the interactions of p53 with MDM2 and MDMX: 《Chinese Chemical Letters》2022年第3期1254-1258,共5页Hongjin Li Xiangyan Chen Minghao Wu Panpan Song Xia Zhao; supported by National Natural Science Foundation of China-Shandong Joint Fund (No. U1606403);Innovation Project of Qingdao National Laboratory for Marine Science and Technology (No. 2015ASKJ02)。; In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor prot...; 关键词：P53 MDM2 MDMX All-hydrocarbon stapling strategy Lactam stapling strategy Bicyclic stapling strategy

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression被引量：2: 《Acta Pharmaceutica Sinica B》2021年第9期2655-2669,共15页Xiang Li Neelakshi Gohain Si Chen Yinghua Li Xiaoyuan Zhao Bo Li William D.Tolbert Wangxiao He Marzena Pazgier Honggang Hu Wuyuan Lu; supported by grants from the National Natural Science Foundation of China,No.21807112(to Xiang Li),No.82030062(to Wuyuan Lu),Nos.91849129 and 22077078(to Honggang Hu);Shanghai Rising-Star Program(to Xiang Li,China);supported by the U.S.Department of Energy,Office of Science,Office of Basic Energy Sciences under Contract No.DE-AC02-76SF00515;supported by the DOE Office of Biological and Environmental Research,and by the National Institutes of Health,National Institute of General Medical Sciences; Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53 in vitro and in vivo,representing a viable therapeutic strategy for cancer treatment....; 关键词：MDM2 MDMX P53 Antitumor peptide Systematic mutational analysis

MDM2/MDMX-p53双靶点蛋白增效厄洛替尼抗胰腺癌活性的研究被引量：2: 《肿瘤预防与治疗》2021年第2期99-107,共9页井佳瑜董丹凤樊杨威吴胤瑛李恩孝董旭媛; 陕西省自然科学基金(编号:2020JQ-505)。; 目的:因对总生存时间的提高仅0.4个月,厄洛替尼在胰腺癌中的应用一直存在争议。本课题组前期成功合成了可阻断MDM2/MDMX-P53的抑制蛋白,本研究拟通过联合该抑制蛋白探讨提高厄洛替尼在胰腺癌中的抗肿瘤活性的可行性。方法:MTT法检测细...; 关键词：MDM2/MDMX-p53抑制蛋白厄洛替尼胰腺癌

MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment: 《Journal of Molecular Cell Biology》2020年第9期713-722,共10页Bing Wang Chuan-Bian Lim Jiawei Yan Lizhen Li Jufang Wang John B.Little Zhi-Min Yuan; This work was supported in part by the Morningside Foundation,the Zhu Fund,and grants from the National Cancer Institute at the National Institutes of Health(RO1CA233558,R01CA167814,and R01CA125144)to Z.-M.Y.; A role of tumor-suppressive activity of p53 in the tumor microenvironment(TME)has been implicated but remains fairly understudied.To address this knowledge gap,we leveraged our MdmxS314A mice as recipients to investig...; 关键词：P53 MDMX tumor microenvironment immune cell infiltration macrophage polarization

MDM2/MDMX异二聚体及MDMX磷酸化调控p53的研究进展被引量：1: 《生命科学》2020年第5期446-452,共7页王兵王菊芳; 甘肃省科技计划项目(145RTSA012,17JR5RA307)。; p53作为肿瘤抑制因子在维持机体内稳态和抑制肿瘤发生发展中起到关键作用。超过半数的人类肿瘤中都存在p53的突变。突变的p53具有"获得性功能",反而促进肿瘤的发生、转移和耐药。MDM2和MDMX是两个最主要的p53负调控蛋白,二者是同源蛋白...; 关键词：P53 MDM2/MDMX异二聚体 MDMX磷酸化肿瘤治疗

MDM2/MDMX双靶点抑制蛋白在p53突变型乳腺癌中的作用及机制被引量：3: 《现代肿瘤医学》2020年第5期713-719,共7页耿倩倩陈南征董丹凤吴胤瑛李恩孝; 国家自然科学基金资助项目(编号:81803015); 目的:明确MDM2/MDMX双靶点抑制蛋白在p53突变型乳腺癌中的抗肿瘤作用及可能机制。方法:采用MTT比色法检测细胞增殖、流式细胞仪测定细胞周期和Annexin V/FITC-PI双染法检测细胞凋亡,明确MDM2/MDMX抑制蛋白对mt-p53乳腺癌的抗肿瘤活性。...; 关键词：MDM2 MDMX 重组蛋白突变型P53 乳腺癌

MDM2/MDMX双靶点抑制剂的研究进展: 《广东化工》2019年第11期118-120,共3页林春敏龚沙沙丁振华孙海鹰; 国家自然科学基金青年项(81602952); p53是一种重要的肿瘤抑制蛋白,在大约50%的肿瘤细胞中p53因发生变异丧失肿瘤抑制功能,而在另外50%带有野生型p53的肿瘤细胞中其功能被抑制。MDM2和MDMX是p53的主要抑制剂,阻断MDM2和MDMX与p53的相互作用可以恢复野生型p53的功能,促使肿...; 关键词：P53 MDM2 MDMX 细胞凋亡双靶点抑制剂抗肿瘤药物

The long and the short of it:the MDM4 tail so far被引量：3: 《Journal of Molecular Cell Biology》2019年第3期231-244,共14页Sue Haupt Javier Octavio Mejia-Hernandez Reshma Vijayakumaran Simon P.Keam Ygal Haupt; The mouse double minute 4(MDM4)is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight,largely due to its therapeutic possibilities.MDM4 is a vital regulator of the tumor su...; 关键词：MDMA MDMX MDM4-FL MDM4-S p53 MDM2 cancer

A dimethylbromobenzene-cysteine stapled peptide dual inhibitor of the p53-MDM2/MDMX interactions: 《Hepatoma Research》2019年第2期1-11,共11页Wei Jiang Liang Jin Min Liu Peng Hou Wang-Xiao He; This work was supported by the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University(XJTU1AF-CRF-2017-003)to Hou P and He WX.; Aim:Hepatocellular carcinoma(HCC)has emerged as one of the most commonly diagnosed forms of human cancer;yet,the current treatment for HCC is less effective than those used against other cancers.Transcription factor p...; 关键词：Hepatocellular carcinoma P53 stapled peptide dimethylbromobenzene-cysteine

MDMX