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Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent被引量：26
《Cell Research》2010年第3期345-356,共12页Hong Jiang Ning Song Huamin Xu Shuzhen Zhang Jun Wang Junxia Xie 
We thank Dr Wei-dong Le for providing the MES23.5 cell line. This work was supported by grants from the National Program of Basic Research sponsored by the Ministry of Science and Tech- nology of China （2006CB500704）, the National Natural Science Foundation of China （30930036, 30770757, 30870858） and the Natural Science Fund of Shandong Province for Distinguished Young Scholars （JQ200807）.
Iron plays a key role in Parkinson＇s disease （PD）. Increased iron content of the substantia nigra （SN） has been found in PD patients, and divalent metal transporter 1 （DMT1） has been shown to be up-regulated in...
关键词：divalent metal transporter 1 iron iron regulatory protein Parkinson＇s disease oxidative stress ANTIOXIDANT 
A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of BT-H1被引量：55
《Cell Research》2008年第8期846-857,共12页Huiming Sheng 
Acknowledgments We thank Dr Yi Zhang （Department of Cell Biology, Institute of Basic Medical Sciences, Beijing, China） for helpful discussions. This work was supported by National Basic Research Program of China （Grant No. 2005CB5227053）, National Natural Science Foundation of China （Grant No. 30671945）, Science and Technology Commission of Shanghai Municipality （No. 06JC 14044 and 07JC 14070）, Shanghai Leading Academic Discipline Project （T0206）, Shanghai Institute of Immunology Academic Project （No. 07-A04, to Ningli Li） and Leading Academic discipline project （IRT0637, Education ministry of China）.
Bone-marrow-derived mesenchymal stem cells （MSCs） have been shown to possess immunosuppressive properties, e.g., by inhibiting T cell proliferation. Activated T cells can also enhance the immunosuppression ability o...
关键词：mesenchymal stem cells （MSCs） IMMUNOSUPPRESSION IFNΓ B7-H 1 siRNA proliferation inhibition 
Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage被引量：5
《Cell Research》2007年第6期531-536,共6页Yuting Lin Junichi Fukuchi Richard A Hiipakka John M Kokontis Jialing Xiang 
Bcl-2 is an anti-apoptotic oncoprotein and its protein levels are inversely correlated with prognosis in many cancers. However, the role of Bcl-2 in the progression of prostate cancer is not clear. Here we report that...
关键词：BCL-2 prostate cancer progression apoptosis androgen-dependtance 
Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β被引量：5
《Cell Research》2006年第8期702-712,共11页Li Wang Fang Du Qi Cao Huiming Sheng Baihua Shen Yan Zhang Yingna Diao Jingwu Zhang Ningli Li 
Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reactions to deplete autoreactive T cells, which are involved in autoimmune diseases. However, it is unknown whether attenuated act...
关键词：anti-tumor immunity IMMUNIZATION autologous T cells GADD45Β AICD 
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