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TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis
《Genes & Diseases》2025年第1期327-340,共14页Cheng Qiu Lin Cheng Derun Di Ziqian Xiang Congyu Wang Jinghang Li Yinuo Xiong Manyu Li Jingwei Liu Jian Zhou Tianyi Liu Xinyu Wang Dan Luo Xiaoxiong Wang Shangye Li Hui Wang Xia Wang Yunpeng Zhao Xinyu Liu Lianlei Wang 
supported in part by the National Natural Science Foundation of China(No.81874022 and 82172483 to Xinyu Liu,No.82102522 to Lianlei Wang);Key R&D Project of Shandong Province(China)(No.2022CXGC010503 to Xinyu Liu);Shandong Natural Science Foundation(No.ZR202102210113 to Lianlei Wang);Shandong Province Taishan Scholar Project(No.tsqn 202211317 to Lianlei Wang);National High Level Hospital Clinical Research Funding(No.2022-PUMCH-D-004).
Intervertebral disc degeneration(IDD)is a common chronic inflammatory degenerative disease that causes lower back pain.However,the underlying mechanisms of IDD remain unclear.Ferroptosis suppressor protein 1(FSP1)is a...
关键词：Caspase 3 FSP1 iFSP1 Intervertebraldisc degeneration NF-ΚB TNFΑ 
Plantamajoside improves type 2 diabetes mellitus pancreaticβ-cell damage by inhibiting endoplasmic reticulum stress through Dnajc1 up-regulation
《World Journal of Diabetes》2025年第2期183-196,共14页Duo Wang Yuan-Song Wang Hong-Min Zhao Peng Lu Meng Li Wei Li Huan-Tian Cui Zhong-Yong Zhang Shu-Quan Lv 
Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.4(2022).
BACKGROUND Plantamajoside(PMS)has shown potential in mitigating cell damage caused by high glucose(HG)levels.Despite this,the precise therapeutic effects of PMS on type 2 diabetes mellitus(T2DM)and the underlying regu...
关键词：Type 2 diabetes mellitus Plantamajoside TRANSCRIPTOMICS Islet beta cell injury MIN6 cell Endoplasmic reticulum stress Dnajc1 
XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation
《Genes & Diseases》2024年第5期350-359,共10页Yun Zhang Susan Lin Jing Yao Wantong Cai Huaqiu Chen Ailikemu Aierken Zhe Wang Weihong Song 
This work was supported by the National Natural Science Foundation of China(No.82201576);Beijing Hospitals Authority Youth Programme(China)(No.QML20210804);Beijing Medical Research 2021-8;Key Laboratory of Alzheimer's Disease of Zhejiang Province of China(No.ZJAD-2021004 to YZ);the National Natural Science Foundation of China(No.82230043 to WS).
As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been im...
关键词：b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1 
Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression
《Genes & Diseases》2024年第5期456-469,共14页Lixin Liang Tian Cai Xiaojia Li Jianhong An Sen Yu Yang Zhang Fengjie Guo Fang Wei Jie He Keping Xie Tingting Jiang 
Guangzhou Ruiqian Biotech Company(China)(No.20230330 to TJ);the National Natural Science Foundation of China(No.82072632);Guangzhou Municipality Bureau of Science and Technology,Guangzhou,China(No.202102010033);the Natural Science Foundation of Guangdong Province,China(No.2022A1515012585 to KX).
Transcriptional factor Forkhead box M1(FOXM1)plays an important role in pancreatic ductal adenocarcinoma(PDAC)development and progression.The molecular mechanisms underlying its dysregulation remain unclear.We identif...
关键词：FOXM1 Gene expression Gene regulation MICRORNA Pancreatic cancer Targeted therapy 
Up-regulation of miR-10a-5p expression inhibits the proliferation and differentiation of neural stem cells by targeting Chl1
《Acta Biochimica et Biophysica Sinica》2024年第10期1483-1497,共15页Juan Zhang Lihong Yang Yuqing Sun Li Zhang Yufei Wang Ming Liu Xiujuan Li Yuxiang Liang Hong Zhao Zhizhen Liu Zhiyong Qiu Ting Zhang Jun Xie 
supported by the grants from the National Natural Science Foundation of China(No.81671462);the Fund for Shanxi“1331 Project”Key Subjects Construction(No.1331KSC);the Natural Science Foundation of Shanxi Province(Nos.20210302124184 and 20210302124016);the Shanxi Province Key Laboratory of Birth Defects and Cell Regeneration and Research Project Supported by Shanxi Scholarship Council of China.
Neural tube defects(NTDs)are characterized by the failure of neural tube closure during embryogenesis and are considered the most common and severe central nervous system anomalies during early development.Recent micr...
关键词：neural tube defects retinoic acid miR-10a-5p cell adhesion molecule L1-like(Chl1) ERK1/2 MAPK signaling pathway 
CHD4-induced up-regulation of ERα activity contributes to breast cancer progression
《Genes & Diseases》2024年第3期132-135,共4页Aman Sattout Xiaomin Yu Zhuo Sun Yanan Li Yulin Li Shujing Li Wei Huo Huijian Wu 
We thank Professor Wei Cheng(Dalian Medical University)for generously offering T47D,MCF7,ZR-75-1,and SK-BR-3 breast cancer cells and Professor WeiGuo Zhu(Peking University Health Science Center)for providing the full-length human Flag-CHD4,GFP-CHD4,and GST-CHD4 plasmids.
The estrogen signaling system is a crucial regulator of metabolicandphysiologicalprocesses.However,abnormal activation of estrogen signaling may play a role in breast cancer initiation and progression.Crucial to this ...
关键词：BREAST CANCER ERΑ 
Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression被引量：1
《Genes & Diseases》2024年第2期921-934,共14页Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting Jiang Muyuan Ma Shaojiang Zheng Junli Guo Keping Xie 
supported by the Jiangxi Science Fund for Distinguished Young Scholars(China)(No.20212ACB216012);the Funding Program for Academic and Technical Leaders of Main Subjects in Jiangxi Province,China(No.20213BCJ22009 to H.Q.Zhang);the National Natural Science Foundation of China(No.81460372 to H.Q.Zhang,No.81960528 to S.Zheng);the Hainan Province Science and Technology special fund(China)(ZDYF2020132 to S.Zheng);the Innovation Platform for Academicians of Hainan Province(China)(YSPTZX202208 to S.Zheng);Hainan Province Clinical Medical Center(QWYH2021276);the Cardiovascular Disease Research Science Innovation Group of Hainan Medical University(China).
Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and context.Ho...
关键词：Growth INVASION METASTASIS Pancreatic cancer UTX 
E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis
《Journal of Clinical and Translational Hepatology》2024年第1期25-35,共11页Cuicui Xiao Jiao Gong Yusheng Jie Weicheng Liang Yan Tai Wei Qin Tongyu Lu Yutian Chong Ziqing Hei Bo Hu Qi Zhang 
supported by the Natural Science Foundation of China(81870449,81670601,81370555,82100693,82170674,81902886,U22A20276);Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(GDUPS,2017);the Science and Technology Program of Guangzhou,China(201903010039,2019B020228001,202206010072,202102020310,202102010155);International cooperation project of Guangdong science and technology plan(2019B020228001,2020A0505100034);Guangdong Basic and Applied Basic Research Foundation(2022A 1515110316,2020A1515110687);Natural Science Foundation of Guangdong Province,(2022A1515012453);Medical Scientific Research Foundation of Guangdong Province,China,(A2020120)Sun Yat-sen University Clinical Research 5010 Program(2016009).
Background and Aims:As a subunit of the condensin complex,NCAPG has an important role in maintaining chromosome condensation,but its biological function and regulatory mechanism in hepatocellular carcinoma(HCC)remains...
关键词：NCAPG Hepatocellular carcinoma PYROPTOSIS NLRP3 inflammasome Serum marker circulating RNA. 
Curcumin attenuates iron-overloaded stress to macrophages via up-regulation of SOD and Nrf2
《Traditional Medicine Research》2023年第8期68-75,共8页Lin-Chao Zhu Pan-Li Tan Ju-Qin Sun Yi-Min Yao 
Background:It is known to all that iron overload is a fatal adverse effect on cells and tissue.Herein,our study aimed to investigate the effects of curcumin on iron-overloaded stress in macrophages.Methods:Ferric ammo...
关键词：iron overload CURCUMIN superoxide dismutase NRF2 MACROPHAGE 
Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice被引量：2
《Acta Pharmacologica Sinica》2023年第7期1337-1349,共13页Zi-hua Song Xiang-Jie Song Chen-ling Yang Peng Cao Yu Mao Yan Jin Meng-yun Xu Hai-tao Wang Xia Zhu Wei Wang Zhi Zhang Wen-juan Tao 
the National Natural Science Foundation of China(grants 32025017,32121002,81971264,and 32271176);CAS Project for Young Scientists in Basic Research(YSBR-013);Natural Science Foundation of Anhui Province(KJ2020A0138).
Diabetic patients frequently experience neuropathic pain,which currently lacks effective treatments.The mechanisms underlying diabetic neuropathic pain remain unclear.The anterior cingulate cortex(ACC)is well-known to...
关键词：diabetic neuropathic pain anterior cingulate cortex MICROGLIA glutamatergic neurons microglia-neuron communication CXCL12/CXCR4 signaling MINOCYCLINE AMD3100 
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