UP-REGULATION

作品数：166被引量：662H指数：12
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XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation
《Genes & Diseases》2024年第5期350-359,共10页Yun Zhang Susan Lin Jing Yao Wantong Cai Huaqiu Chen Ailikemu Aierken Zhe Wang Weihong Song 
This work was supported by the National Natural Science Foundation of China(No.82201576);Beijing Hospitals Authority Youth Programme(China)(No.QML20210804);Beijing Medical Research 2021-8;Key Laboratory of Alzheimer's Disease of Zhejiang Province of China(No.ZJAD-2021004 to YZ);the National Natural Science Foundation of China(No.82230043 to WS).
As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been im...
关键词：b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1 
Up-Regulation of Akt and Nav1.8 in BmK I-Induced Pain被引量：2
《Neuroscience Bulletin》2018年第3期539-542,共4页Guokun Zhou Yunlu Jiao You Zhou Shichao Qin Jie Tao Feng Jiang Zhi-Yong Tan Yong-Hua Ji 
supported by grants from the National Natural Science Foundation of China (31571032, 31771191, and 81402903);supported by an Indiana Spinal Cord and Brain Injury Research Fund grant (ISCBIRF2017)
Dear Editor,As the key contributor to the rising phase of action potentials in dorsal root ganglion（DRG）neurons,voltagegated sodium channels（VGSCs）are important in physiological and pathological pain conditions.Fo...
关键词：Akt In Up-Regulation of Akt and Nav1.8 in BmK I-Induced Pain 
Hypotriglyceridemic Effects of Apple Polyphenols Extract via Up-Regulation of Lipoprotein Lipase in Triton WR-1339-Induced Mice被引量：4
《Chinese Journal of Integrative Medicine》2014年第1期31-35,共5页姚楠 何蓉蓉 曾晓会 黄雪君 杜铁良 崔景朝 栗原博 
Objective：To investigate the anti-hyperlipidemic effects of apple polyphenols extract（APE）in Triton WR-1339-induced endogenous hyperlipidemic model.Methods：Firstly,APE was isolated and purified from the pomace of ...
关键词：apple polyphenols extract Triton WR-1339 TRIGLYCERIDE lipoprotein lipase peroxisome proliferator-activated receptor alpha 
β-VLDL induced VLDL-R's Up-regulation via PKC-ERK1/2 Signal Pathway
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2004年第4期314-317,共4页刘志国 王燕 屈伸 冯友梅 吴凡 宗义强 赵则春 
ThisprojectwassupportedbyagrantfromtheNationalNaturalSciencesFoundationofChina (No.39970 30 7)
To explore the intracellular signal pathways for β-VLDL induced very low density lipoprotein receptor (VLDL-R) transcription up-regulation and their effects on lipid accumulation in macrophages, Western Blot was used...
关键词：VLDL receptor β-VLDL signal transduction ERK1/2 lipid accumulation 
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