the National Key Research and Development Program of China(2021YFC400600,2022YFE0203600);the National Natural Science Foundation of China(81925035 and 82341232);the Future Network(083GJHZ2023012FN);Grand Challenges(083GJHZ2023021GC)of the International Partnership Program of the Chinese Academyof Sciences,CAS President’s International Fellowship Initiative(2024VBB0004);High-level Innovative Research Institute(2021B0909050003)from Department of Science;Technology of Guangdong Province;Zhongshan Municipal Bureau of Science and Technology(LJ2021001 and CXTD2022011).
Glycolysis-related lactic acid overproduction creates an“ion-trapping”barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of ...