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Wnt signaling and Loxl2 promote aggressive osteosarcoma被引量：13
《Cell Research》2020年第10期885-901,共17页Kazuhiko Matsuoka Latifa Bakiri Lena I.Wolff Markus Linder Amanda Mikels-Vigdal Ana Patiño-García Fernando Lecanda Christine Hartmann Maria Sibilia Erwin F.Wagner 
We thank Drs.Mirna Perez-Moreno,Monica Musteanu and Mariano Barbacid for sharing reagents,protocols and helpful suggestions,Massimo Squatrito for invaluable help with human data analyses and Jean-Pierre David,who unfortunately passed away recently,and Agamemnon Grigoriadis for critical reading of the manuscript.We are grateful to members of the Wagner laboratory for discussions,V.Bermeo for technical help;S.Leceta,G.Medrano and P.García for assisting with mouse experiments,the staff at the Imaging Unit at CNIO for help with Micro-CT and G.Timelthaler at the MUV/Institute of Cancer Research Core facilities for help with TMA digital acquisition and analysis.K.M.was the recipient of grants from the Uehara Memorial Foundation and the AECC.The Wagner laboratory is supported by the ERC(ERC‐AdG 2016 CSI‐Fun)and the Medical University of Vienna(MUV).
Osteosarcoma(OS)is the most frequent primary malignant bone tumor in urgent need of better therapies.Using genetically modified mouse models(GEMMs),we demonstrate that Wnt signaling promotes c-Fos-induced OS formation...
关键词：OSTEOSARCOMA WNT AGGRESSIVE 
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