CHLOROQUINE

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相关机构：中国医学科学院北京协和医学院复旦大学中山大学附属第一医院中山大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划江苏省自然科学基金更多>>
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Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum被引量：1
《Acta Pharmaceutica Sinica B》2020年第9期1680-1693,共14页Kun Zhang Yu Zhao Zheng Zhang Mengyao Zhang Xiaodong Wu Huijie Bian Ping Zhu Zhinan Chen 
supported by the National Science and Technology Major Project(2019ZX09732001,China);the National Basic Research Program of China(2015CB553701,China)
Meplazumab is an anti-CD147 humanized IgG2 antibody.The purpose of this study was to characterize the nonclinical safety,tolerance and efficacy evaluation of meplazumab treating chloroquine resistant Plasmodium falcip...
关键词：Meplazumab CD147 Safety TOLERANCE Efficacy NONCLINICAL Plasmodium falciparum Antimalarial therapy 
Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques被引量：7
《Cellular & Molecular Immunology》2012年第5期410-416,共7页Jian-Ping Ma Hou-Jun Xia Gao-Hong Zhang Jian-Bao Han Li-Guo Zhang Yong-Tang Zheng 
ACKNOWLEDGEMENTS This work was supported in part by grants from the National Basic Research Program of China （2009CB522306 and 2012CBA01305）, the National Natural Science Foundation of China （30872317, 30800113, U0832601 and 81172876）, the Knowledge Innovation Program of CAS （KSCX1-YW-10 and KSCX2-EW-R-13）, the Key Scientific and Technological Program of China （2009ZX09501-029, 2012ZX10001-006 and 2012ZX10001-007） and Yunnan province （2010GA001） and the ＇Western Light＇ Projects of the CAS. The funding organizations had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
It is currently widely accepted that immune activation in HIV-infected individuals leads to a severe loss of CD4＋ T cells and the progression to AIDS. However, the underlying mechanism of this immune activation remai...
关键词：Chinese rhesus macaque CHLOROQUINE immune activation pDC SIV 
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