This study was supported by Capital’s Funds for Health Improvement and Research of Beijing Children’s Hospital,Capital Medical University(No.2020-2-2094);the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-026);We would like to thank all the families and individuals who participated in this study,and appreciate all the staffs in the PICU from the four centers.
Importance Acute necrotizing encephalopathy(ANE)is a rare disease with high mortality.Plasma exchange(PLEX)has recently been reported to treat ANE of childhood(ANEC),but its efficacy is uncertain.Objective This study ...