supported by STI2030-Major Projects(2022ZD0204900);the National Natural Science Foundation of China(NSFC)(91632103,31900732,31771157);the Program of Shanghai Subject Chief Scientist(17XD1401700);National Key Research and Development Program of China(2018YFE0126700);the Shanghai Education Commission Research and Innovation Program(2019-01-07-00-02-E00037);Natural Science Foundation of Chongqing cstc2021jcyjmsxmX1176,the‘111’Program of Higher Education Discipline Innovation,‘Eastern Scholar’(Shanghai Municipal Education Commission),Shanghai Municipal Commission of Science and Technology Program(21dz2210100);China Postdoctoral Science Foundation(202N1702133,2021M702137);The National Science Fund for Distinguished Young Scholars(31900732).
Background Kabukisyndrome(KS)is arare developmental disorder characterised by multiple congenital anomalies and intellectual disability.UTX(ubiquitously transcribed tetratricopeptide repeat,X chromosome),which encodes...