DESIPRAMINE

作品数：6被引量：1H指数：1
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相关领域：医药卫生更多>>
相关作者：祁红金正均陈红专李云峰罗质璞更多>>
相关机构：上海第二医科大学军事医学科学院山西医科大学上海医药工业研究院更多>>
相关期刊：《Acta Pharmacologica Sinica》《General Psychiatry》更多>>
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Desipramine reverses remote memory deficits by activating calmodulin- CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome
《General Psychiatry》2024年第5期522-531,共10页Lei Chen Yuting Li Minggang Liu Zhaohui Lan Xu Zhang Xiujuan Yang Qian Zhao Shuai Wang Longyong Xu Ying Zhou Yifang Kuang Tatsuo Suzuki Katsuhiko Tabuchi Eiki Takahashi Miou Zhou Charlie Degui Chen Tianle Xu Weidong Li 
supported by STI2030-Major Projects(2022ZD0204900);the National Natural Science Foundation of China(NSFC)(91632103,31900732,31771157);the Program of Shanghai Subject Chief Scientist(17XD1401700);National Key Research and Development Program of China(2018YFE0126700);the Shanghai Education Commission Research and Innovation Program(2019-01-07-00-02-E00037);Natural Science Foundation of Chongqing cstc2021jcyjmsxmX1176,the‘111’Program of Higher Education Discipline Innovation,‘Eastern Scholar’(Shanghai Municipal Education Commission),Shanghai Municipal Commission of Science and Technology Program(21dz2210100);China Postdoctoral Science Foundation(202N1702133,2021M702137);The National Science Fund for Distinguished Young Scholars(31900732).
Background Kabukisyndrome(KS)is arare developmental disorder characterised by multiple congenital anomalies and intellectual disability.UTX(ubiquitously transcribed tetratricopeptide repeat,X chromosome),which encodes...
关键词：IMPAIRED reversed UTX 
Protective effects of curcumin on desipramine-induced isletβ-cell damage via AKAP150/PKA/PP2B complex
《Acta Pharmacologica Sinica》2024年第2期327-338,共12页Min Hu Jia-ying Cai Yao He Kui Chen Feng Hao Jin-sen Kang Yan Pan Lu Tie Xue-jun Li 
supported by the National Natural Science Foundation of China(No.92168120,81974506,81673486 and 81373405 to Lu Tie,No.82073878,81020108031 and 81874318 to Xue-jun Li);the Beijing Natural Science Foundation(No.Z200019 and 7172119)to Lu Tie.
Tricyclic antidepressants(TCAs)are widely used to treat depression and anxiety-related mood disorders.But evidence shows that TCAs elevate blood glucose levels and inhibit insulin secretion,suggesting that TCAs are a ...
关键词：tricyclic antidepressants DESIPRAMINE insulin secretion 
Caspase 3 gene expression and [Ca<sup>2+</sup>]<sub>i</sub> homeostasis underlying desipramine-induced C6 glioma cell apoptosis
《Acta Pharmacologica Sinica》2002年第9期37-41,共页祁红 陈红专 金正均 
AIM: To study desipramine (Des)-induced apoptosis and regulation of caspase 3 gene expression and [Ca2+]i homeostasis in rat glioma C6 cells. METHODS: Apoptotic DNA breaks were quantified by propidium iodide (PI) inco...
关键词：DESIPRAMINE GLIOMA apoptosis CASPASES calcium 
Caspase 3 gene expression and [Ca^(2+)]_i homeostasis underlying desipramine-induced C6 glioma cell apoptosis
《Acta Pharmacologica Sinica》2002年第9期803-807,共5页祁红 陈红专 金正均 
Project supported by the Science and Technology Development Foundation of Shanghai(№ S990208).
AIM: To study desipramine (Des)-induced apoptosis and regulation of caspase 3 gene expression and [Ca2+]i homeostasis in rat glioma C6 cells. METHODS: Apoptotic DNA breaks were quantified by propidium iodide (PI) inco...
关键词：DESIPRAMINE GLIOMA apoptosis CASPASES calcium 
Desipramine antagonized corticosterone-induced apoptosis in cultured PC12 cells被引量：1
《Acta Pharmacologica Sinica》2002年第4期311-314,共4页李云峰 罗质璞 
AIM: To study possible action mechanism of a tricyclic antidepressant, desipramine (DIM). METHODS: Cultured PC12 cells were exposed to corticosterone in the absence or presence of DIM for 5 d. Agarose gel electrophore...
关键词：DESIPRAMINE antidepressive agents CORTICOSTERONE PC12 cells APOPTOSIS 
Norepinephrine metabolism in neuron: dissociation between 3, 4-dihydroxyphenylglycol and 3,4-dihydroxymandelic acid pathways
《Acta Pharmacologica Sinica》2002年第1期61-67,共7页董文心 倪湘莲 
To investigate the pre-synaptic metabolism of norepinephrine ( NE), judged by variations in plasma concentration of 3,4-dihydroxyphenylglycol (DHPG) and 3,4-dihydroxymandelic acid (DOMA). METHODS: Pithed and electrica...
关键词：norepinephnne METABOLISM mono-amine oxidase DESIPRAMINE DEPRENYL CLORGYLINE 
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