supported by the National Key Research and Development Program of China(2017YFC1001501,2016YFC1000604,2018YFC1004002);the Foundation for Innovative Research Groups of National Natural Science Foundation of China(81521002)。
Primordial germ cells(PGCs)are precursors of both male and female gametes as fundamental materials for organism development.The transcriptome,methylome,and chromatin accessibility profiles of PGCs in both mice and hum...
Embryonic stem cells(ESCs)are pluripotent and can self-assemble to form cell clusters or embryoid bodies(EBs),which can then differentiate into all cell types of the three germ layers,as among which one is the pri...