Depression is a recurring and potentially lifethreatening disorderthat is major cause of morbidity and mor-tality. Stressful eventscan precipitate factors in the onset of major depressionand stress paradigms have long...
PDE is a supeffamily of enzymes that break down the important second messengers cyclic AMP (cAMP) PDE4 is the most important fami- and cyclic GMP (cGMP). There are 11 PDE families ( PDEI-11 ) ; among them, ly i...