This work is financially supported by the National Key R&D Program of China(2018YFA0704000);the National Natural Science Foundation of China(21807074,51802202,31900945,82071985);Shenzhen Science and Technology Program(KQTD20190929172538530,JCYJ20180507182413022,JCYJ20170412111100742);the Guangdong Province Natural Science Foundation of PhD Start-up Fund(2018A030310574 and 2018A030310566);the Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project(2018B030308003);the Fundamental Research Funds for the Central Universities(2020CDJQY-A060).
In recent years,metal peroxide(MO_(2))such as CaO_(2) has received more and more attention in cancer treatment.MO_(2) is readily decompose to release metal ions and hydrogen peroxide in the acidic tumor microenvironme...