ANALGESICS

作品数：57被引量：92H指数：5
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Rhodauricanol A, an analgesic diterpenoid with an unprecedented5/6/5/7 tetracyclic system featuring a unique16-oxa-tetracyclo[11.2.1.0^(1,5).0^(7,13)]hexadecane core from Rhododendron dauricum被引量：1
《Chinese Chemical Letters》2023年第4期183-187,共5页Yuanyuan Feng Suqin Zha Hanqi Zhang Biao Gao Guijuan Zheng Pengfei Jin Yingyi Chen Guangmin Yao 
supported by the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (NoP2022-KF08);National Natural Science Foundation of China (Nos.22107033 and U1703109);the Scientific Research Project of Traditional Chinese Medicine of Hubei Provincial Health Commission (No. ZY2021M056)。
A novel diterpenoid with an unprecedented 5/6/5/7 tetracyclic system, rhodauricanol A(1), five new grayanane-derived diterpenoids, dauricanols A-E(2-6), and five known ones(7-11) were isolated from the flowers of Rhod...
关键词：Rhododendron dauricum L.(Ericaceae) Diterpenoids Single-crystal X-ray diffraction Biosynthetic pathways ANALGESICS 
Synthesis and evaluation of peptide-fentanyl analogue conjugates as dualμ/δ-opioid receptor agonists for the treatment of pain被引量：1
《Chinese Chemical Letters》2022年第8期4107-4110,共4页Jing Li Tao Zhang Jialin Sun Fengxia Ren Hongxin Jia Zixing Yu Jingchao Cheng Weiguo Shi 
Novel peptide-fentanyl analogue conjugates were synthesized by the covalent coupling of carfentanyl derivatives to the C-terminus or N-terminus of the conformationally constrained dermorphin tetrapeptide BVD03 via a c...
关键词：Peptide-small molecule conjugates Dual MOR/DOR agonists Lead compound ANALGESICS Physical dependence 
Endomorphin analogues with balanced affinity for bothμ- andδ-opioid receptors被引量：4
《Chinese Chemical Letters》2011年第8期907-910,共4页Liang Zhang Lei Chang Lei Lei Yu Jin Chun Liu Jia Jia Chen Xiao Wen Li Lawrence H. Lazarus Ting You Li 
was supported by grants 08KJB350002 and 08NMUZ028;in part by the Intramural Research Program of the NIH and NIEHS
Analogues of endomorphin and tripeptidcs modified at positions 4 and 3,respectively,with various phenylalanine analogues were synthesized and their affinities for opioid receptors were evaluated.Most of the peptides e...
关键词：ENDOMORPHIN OPIOID ANALGESICS 
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