Α-KETOGLUTARATE

作品数：13被引量：15H指数：2
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相关领域：医药卫生更多>>
相关机构：南华大学更多>>
相关期刊：《Journal of Biomedical Research》《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金更多>>
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IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbingα-ketoglutarate-related metabolism and epigenetic modification
《Life Metabolism》2024年第2期24-37,共14页Yuanlin Zhao Ying Yang Risheng Yang Chao Sun Xing Gao Xiwen Gu Yuan Yuan Yating Nie Shenhui Xu Ruili Han Lijun Zhang Jing Li Peizhen Hu Yingmei Wang Huangtao Chen Xiangmei Cao Jing Wu Zhe Wang Yu Gu Jing Ye 
supported by funds from the National Key Research and Development Program of China(2022YFA0806501);the National Natural Science Foundation of China(81972342 to J.Y.,82173120 to Y.G.,and 82070298 to L.Z.);the Natural Science Basic Research Plan in ShaanxiProvince(2020JZ-29 to J.Y.).
Isocitrate dehydrogenase(IDH)mutations frequently occur in lower-grade gliomas and secondary glioblastomas.Mutant IDHs exhibit a gain-of-function activity,leading to the production of D-2-hydroxyglutarate(D-2HG)by red...
关键词：Α-KETOGLUTARATE IDH1 mutation OGDH L-GLUTAMINE gliomas 
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